EPITHELIAL OVARIAN CANCER

This study is testing a personalized vaccine for advanced ovarian cancer. The vaccine is made by loading a patient's own tumor material into specialized immune cells (dendritic cells) taken from their blood. The goal is to see if this vaccine, given alongside standard chemotherap…

This study is testing a new oral drug called ETX-19477 in adults with advanced solid tumors that have stopped responding to standard treatments. The main goals are to find a safe dose and see if the drug can help control the cancer. Researchers are especially interested in enroll…

This early-stage study is testing the safety and initial effectiveness of an experimental treatment called 27T51, a type of CAR T-cell therapy, for women with recurrent or hard-to-treat ovarian, primary peritoneal, or fallopian tube cancers. The first part will find the safest do…

This study is testing whether removing specific lymph nodes near the liver and stomach is safe and effective for women with advanced or returning ovarian cancer. Researchers will follow 94 patients who have this specialized surgery to see if it helps control the cancer longer. Th…

This large Phase 3 trial is testing whether a new drug called AZD5335 works better than current standard treatments for women with advanced ovarian cancer that has stopped responding to platinum chemotherapy. About 1100 participants will be assigned to receive either the new drug…

This study is testing an experimental drug called TORL-1-23 for women with advanced ovarian, fallopian tube, or primary peritoneal cancer that has stopped responding to standard platinum-based chemotherapy. The drug specifically targets cancer cells that have a protein called CLD…

This study is testing if giving cancer drugs *before* surgery is a safe and workable strategy for advanced ovarian cancer. It will enroll 60 patients into two groups: one receives the drug olaparib, and the other receives olaparib plus durvalumab. The main goal is to see if patie…

This study is testing whether adding daphnetin capsules to standard chemotherapy helps control advanced ovarian cancer after initial surgery. It involves 98 patients with stage III-IV ovarian cancer who have had successful tumor removal surgery. The goal is to see if this combina…

This study is exploring whether a specific eating schedule, called intermittent fasting, is safe and helpful for people with ovarian cancer who are receiving chemotherapy before surgery. Researchers want to see if not eating for 16 hours a day on certain days can improve patients…

This study is testing a new type of treatment called CAR-NK cell therapy for women with ovarian cancer that has come back or stopped responding to standard treatments. Doctors first check the patient's tumor for specific markers and then give them a personalized infusion of modif…

This study is testing whether a new targeted drug called mirvetuximab soravtansine, when combined with standard chemotherapy (carboplatin), can shrink tumors before surgery in people with advanced ovarian, fallopian tube, or primary peritoneal cancer. The treatment is designed to…

This is the first study in people for a new oral medication called AVZO-021. It aims to find a safe dose and see if the drug can help control advanced solid tumors, including certain types of breast and ovarian cancer, when other standard treatments are no longer working. The stu…

This early-stage study is testing a new type of treatment called CAR-T cell therapy for women with ovarian cancer that has returned and is resistant to standard platinum-based chemotherapy. Doctors will collect a patient's own immune cells, modify them in a lab to better target t…

This study is testing whether a plant-based supplement called isoquercetin can reduce markers in the blood that indicate risk of blood clots in people with ovarian cancer. Researchers will compare the effects of isoquercetin against a placebo in 90 participants who are receiving …

This large Phase 3 trial is testing whether adding a new drug called IMNN-001 to standard chemotherapy helps people with advanced ovarian, fallopian tube, or primary peritoneal cancer live longer. About 500 participants will be randomly assigned to receive either the standard che…

This study is testing a new radioactive tracer called [18F]FPyQCP for PET scans to see if it can better detect five specific cancers: colorectal, ovarian, gastric, breast, and pancreatic. Researchers will check if the tracer is safe, measure its radiation dose, and see how accura…

This study is testing if a special exercise and nutrition program, started during chemotherapy before surgery, can help older adults with advanced ovarian or pancreatic cancer. The goal is to see if patients can stick to the program and if it helps them get stronger, improve thei…

This study aims to discover why some ovarian cancers become resistant to standard platinum-based chemotherapy. Researchers will follow 600 patients for five years, collecting health data and biological samples during their normal treatment. The goal is to identify factors that ca…

This study aims to understand how specific cells in a patient's immune system relate to survival in ovarian cancer. Researchers will collect blood and tissue samples from 300 patients before and during their standard treatments. The goal is to identify biological markers that cou…

This study aims to learn how the immune system behaves in different types of ovarian cancer. Researchers will collect tissue and blood samples from 74 patients before and after their standard cancer surgery or chemotherapy. The goal is to see if certain immune cell patterns can p…