New drug combo aims to fight advanced ovarian cancer before surgery

NCT ID NCT07322094

Recruiting now Disease control Sponsor: TORL Biotherapeutics, LLC Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jul 14, 2026 · Updated 3 times

Summary

This study tests whether adding an experimental drug called TORL-1-23 to standard chemotherapy before surgery can help women with advanced ovarian cancer. About 60 participants with a specific tumor marker (CLDN6) will receive the combination, then undergo surgery. The goal is to see if the treatment is safe and shrinks tumors more effectively.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: TORL-1-23 (an experimental antibody-drug conjugate) combined with chemotherapy drugs paclitaxel and carboplatin
What this could lead to: If successful, this could lead to a new treatment option that improves outcomes for women with advanced ovarian cancer.
What could go wrong: This is an early-phase trial with only 60 participants, so results may not apply broadly. The drug combination may cause serious side effects or fail to improve survival.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

fallopian tube cancer fallopian tube neoplasm ovarian cancer ovarian carcinoma primary peritoneal carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

FALLOPIAN TUBE CANCERS FIGO STAGE III AND IV OVARIAN CANCER PRIMARY PERITONEAL CANCER

Contacts and locations

Locations

City of Hope
RECRUITING

Irvine, California, 92618, United States
Duke University
RECRUITING

Durham, North Carolina, 27705, United States
Mt Sinai Hospital
RECRUITING

New York, New York, 10029, United States
Providence St. Jude Medical Center
RECRUITING

Fullerton, California, 92835, United States
The Mayo Clinic
RECRUITING

Rochester, Minnesota, 55905, United States
UCLA
RECRUITING

Los Angeles, California, 90095, United States
University of Southern California
RECRUITING

Los Angeles, California, 90007, United States

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