Heated chemo during surgery could extend lives in ovarian cancer

NCT ID NCT05827523

Recruiting now Disease control Sponsor: National Cancer Center, Korea Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This Phase 3 trial tests whether adding heated chemotherapy (HIPEC) directly into the abdomen during surgery can help people with advanced ovarian cancer live longer. About 520 participants who have already had some chemo will be randomly assigned to get surgery with or without HIPEC. The main goal is to see if HIPEC improves overall survival.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Cisplatin (heated chemotherapy given directly into the abdomen during surgery)
What this could lead to: If this works, it could become a standard addition to surgery for advanced ovarian cancer, potentially helping people live longer.
What could go wrong: This is a large Phase 3 trial, but heated chemotherapy has risks like infection or organ damage. It may not improve survival enough to outweigh those risks.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Carcinoma, Ovarian Epithelial fallopian tube cancer ovarian cancer ovarian carcinoma primary peritoneal carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

OVARIAN CANCER

Contacts and locations

Locations

Ajou University Hospital
RECRUITING

Suwon, Gyeonggi-do, South Korea
Asan Medical Center
NOT_YET_RECRUITING

Seoul, South Korea
Chungnam National University Hospital
NOT_YET_RECRUITING

Sejong, Chungcheongnam-do, South Korea
Chungnam National University Sejong Hospital
NOT_YET_RECRUITING

Sejong, Chungcheongnam-do, South Korea
Ewha Womans University Mokdong Hospital
NOT_YET_RECRUITING

Seoul, South Korea
Ilsan CHA University Hospital
RECRUITING

Goyang-si, Gyeonggi-do, South Korea
National Cancer Center
RECRUITING

Goyang-si, Gyeonggi-do, South Korea
Pusan National University Hospital
NOT_YET_RECRUITING

Pusan, South Korea
Pusan National University Yangsan Hospital
NOT_YET_RECRUITING

Pusan, South Korea
Severance Hospital
RECRUITING

Seoul, South Korea

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