New genetic score could spot ovarian cancer risk earlier

NCT ID NCT06935344

Recruiting now Knowledge-focused Sponsor: Catholic University of the Sacred Heart Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study is testing whether a polygenic risk score (PRS) — a calculation based on many small genetic variations — can help predict a woman's chance of developing ovarian cancer. Researchers will compare the PRS of 1,300 Italian women, half with ovarian cancer and half without. Participants also provide blood samples and answer lifestyle questions. The goal is to see if adding PRS to known risk factors improves prediction.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If successful, this could lead to better ways to identify women at high risk for ovarian cancer, allowing for earlier monitoring or prevention.
What could go wrong: This is an observational study, not a treatment trial. The polygenic risk score may not prove accurate enough to change clinical practice, and results may not apply to other populations.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

fallopian tube cancer Genetic Risk Score ovarian cancer ovarian carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

OVARIAN CANCER

Contacts and locations

Locations

Dipartimento Universitario di Scienze della Vita e Sanità Pubblica
RECRUITING

Roma, Italia, 00168, Italy

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