New hope for ovarian cancer: experimental drug AZD5335 faces off against standard care

NCT ID NCT07218809

Recruiting now Disease control Sponsor: AstraZeneca Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 22, 2026 · Updated 2 times

Summary

This Phase 3 trial is testing a new drug called AZD5335 against standard treatments (like chemotherapy or another targeted drug) in about 1,100 women with a tough-to-treat type of ovarian cancer that has stopped responding to platinum-based chemotherapy. The goal is to see if AZD5335 can slow cancer growth better than current options. Participants are grouped by whether their tumors have high or low levels of a protein called FRα.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: AZD5335 (an antibody drug conjugate)
What this could lead to: If successful, AZD5335 could offer a new, more effective treatment option for women with platinum-resistant ovarian cancer, potentially slowing disease progression.
What could go wrong: This is a large Phase 3 trial, but the drug is still experimental. It may not prove superior to existing treatments, and side effects from the antibody drug conjugate are possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Carcinoma, Ovarian Epithelial fallopian tube cancer malignant ovarian serous tumor ovarian carcinoma ovarian serous adenocarcinoma primary peritoneal carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

EPITHELIAL OVARIAN CANCER

Contacts and locations

Locations

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Birmingham, Alabama, 35223, United States
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Little Rock, Arkansas, 72205, United States
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La Jolla, California, 92037, United States
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Washington D.C., District of Columbia, 20010, United States
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Fort Lauderdale, Florida, 33316, United States
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Gainesville, Florida, 32608, United States
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Jupiter, Florida, 33458, United States
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Miami, Florida, 33176, United States
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Weston, Florida, 33331, United States
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Chicago, Illinois, 60612, United States
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Evanston, Illinois, 60201, United States
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Peoria, Illinois, 61637, United States
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Urbana, Illinois, 61801, United States
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Fort Wayne, Indiana, 46845, United States
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Indianapolis, Indiana, 46202, United States
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Louisville, Kentucky, 40241, United States
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Towson, Maryland, 21204, United States
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Burlington, Massachusetts, 01805, United States
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Worcester, Massachusetts, 01655, United States
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Minneapolis, Minnesota, 55404, United States
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Springfield, Missouri, 65807, United States
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Billings, Montana, 59106, United States
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Omaha, Nebraska, 68114, United States
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Las Vegas, Nevada, 89106, United States
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Lebanon, New Hampshire, 03756, United States
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Camden, New Jersey, 08103, United States
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The Bronx, New York, 10461, United States
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Chapel Hill, North Carolina, 27599, United States
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Blue Ash, Ohio, 45242, United States
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Dayton, Ohio, 45459, United States
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Sylvania, Ohio, 43560, United States
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Portland, Oregon, 97213, United States
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York, Pennsylvania, 17403, United States
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Germantown, Tennessee, 38138, United States
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San Antonio, Texas, 78229, United States
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Tyler, Texas, 75702, United States
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Salt Lake City, Utah, 84106, United States
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Fairfax, Virginia, 22031, United States
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Roanoke, Virginia, 24016, United States
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Seattle, Washington, 98104, United States
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Adelaide, 5037, Australia
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Auchenflower, 4066, Australia
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Campbelltown, 2560, Australia
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Camperdown, 2050, Australia
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Clayton, 3168, Australia
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Cudgen, 2487, Australia
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Garran, 2605, Australia
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Gosford, 2250, Australia
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Heidelberg, 3084, Australia
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Kogarah, 2217, Australia
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Melbourne, 3000, Australia
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Richmond, 3121, Australia
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St Leonards, 2065, Australia
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Waratah, 2298, Australia
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Charleroi, 6060, Belgium
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Edegem, 2650, Belgium
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Ghent, 9000, Belgium
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Leuven, 3000, Belgium
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Libramont-Chevigny, 6800, Belgium
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Namur, 5000, Belgium
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Barretos, 14784-400, Brazil
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Bela Vista, 1317, Brazil
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Curitiba, 81520-060, Brazil
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Goiânia, 74110-060, Brazil
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Natal, 59075-740, Brazil
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Porto Alegre, 90020-090, Brazil
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Porto Alegre, 90035-903, Brazil
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Porto Alegre, 90610-000, Brazil
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Porto Alegre, 91350200, Brazil
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Porto Velho, 76834-899, Brazil
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Rio de Janeiro, 20230-130, Brazil
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São José do Rio Preto, 15090-000, Brazil
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São Paulo, 01401-002, Brazil
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São Paulo, 01409-902, Brazil
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Edmonton, Alberta, T6G 1Z2, Canada
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Hamilton, Ontario, L8V 5C2, Canada
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Kingston, Ontario, K7L 2V7, Canada
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Montreal, Quebec, H1T 2M4, Canada
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Montreal, Quebec, H3T 1E2, Canada
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Montreal, Quebec, H4A 3J1, Canada
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Québec, G1G 5X1, Canada
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Port Montt, 5480000, Chile
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Providencia, 7510032, Chile
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Santiago, 7500587, Chile
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Santiago, 7500653, Chile
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Santiago, 7520426, Chile
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Santiago, 8330032, Chile
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Santiago, 8331143, Chile
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Santiago, 8420383, Chile
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Viña del Mar, 2520000, Chile
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Beijing, 100021, China
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Beijing, 100142, China
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Beijing, 102600, China
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Bengbu, 233004, China
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Changchun, 130012, China
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Changsha, 410008, China
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Changsha, 410013, China
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Chengdu, 610041, China
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Chongqing, 400030, China
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Fuzhou, 350011, China
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Guangzhou, 510000, China
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Guangzhou, 510060, China
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Guangzhou, 510080, China
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Hangzhou, 310003, China
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Hangzhou, 310006, China
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Hangzhou, 310022, China
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Harbin, 150049, China
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Jinan, 250012, China
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Jinan, 250117, China
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Lanzhou, 730000, China
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Linyi, 276000, China
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Nanchang, 330029, China
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Nanjing, 2100008, China
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Nanjing, 210009, China
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Nanning, 530021, China
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Shanghai, 200025, China
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Shanghai, 200032, China
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Shenyang, 110004, China
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Shenyang, 110042, China
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Shijiazhuang, 050020, China
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Taiyuan, 030000, China
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Tianjin, 300060, China
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Wuhan, 430022, China
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Wuhan, 430030, China
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Wuhan, 430079, China
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Xi'an, 710061, China
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Zhanjiang, 524001, China
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Zhengzhou, 450008, China
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Zhengzhou, 450052, China
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Brno, 625 00, Czechia
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Hradec Králové, 500 05, Czechia
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Nový Jičín, 741 01, Czechia
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Olomouc, 77900, Czechia
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Prague, 12808, Czechia
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Prague, 150 06, Czechia
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Prague, 18000, Czechia
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Aalborg, 9000, Denmark
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Aarhus, 8200, Denmark
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Odense, 5000, Denmark
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Vejle, 7100, Denmark
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Amiens, 80054, France
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Avignon, 84000, France
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Nîmes, 30029, France
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Paris, 75005, France
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Pau, 64046, France
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Pierre-Bénite, 69310, France
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Plerin SUR MER, 22190, France
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Reims, 51056, France
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Saint-Herblain, 44805, France
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Saint-Priest-en-Jarez, 42271, France
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Toulouse, 31300, France
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Tours, 37044, France
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Berlin, 13353, Germany
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Bonn, 53127, Germany
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Detmold, 32756, Germany
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Dresden, 01307, Germany
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Düsseldorf, 40225, Germany
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Essen, 45130, Germany
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Essen, 45147, Germany
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Frankfurt am Main, 60487, Germany
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Hamburg, 20246, Germany
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Hamburg, 22457, Germany
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Hanover, 30625, Germany
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Leipzig, 4103, Germany
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Mannheim, 68167, Germany
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Schwäbisch Hall, 74523, Germany
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Tübingen, 72076, Germany
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Ulm, 89075, Germany
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Wiesbaden, 65199, Germany
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Athens, 11528, Greece
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Athens, 12462, Greece
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Athens, 14564, Greece
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Athens, 15123, Greece
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Kalamata, 24100, Greece
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Pátrai, 26332, Greece
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Rio, 26504, Greece
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Thessaloniki, 55236, Greece
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Bhubaneswar, 751007, India
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Chennai, 600113, India
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Delhi, 110029, India
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Dhanvantari Nagar, 605006, India
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Kolkata, 700017, India
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Nagpur, 440001, India
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Nashik, 422 009, India
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Surat, 395002, India
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Tiruchirappalli, 620008, India
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Cork, T12 DV56, Ireland
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Dublin, 7, Ireland
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Dublin, D08 NHY1, Ireland
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Dublin, DO4YN63, Ireland
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Waterford, X91 ER8E, Ireland
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Afula, 1834111, Israel
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Beersheba, 84101, Israel
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Hadera, 38100, Israel
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Haifa, 3109601, Israel
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Haifa, 34362, Israel
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Holon, 5822012, Israel
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Jerusalem, 00000, Israel
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Jerusalem, 91031, Israel
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Kfar Saba, 4428164, Israel
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Nahariya, 22100, Israel
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Ramat Gan, 52621, Israel
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Sofia, 1680, Israel
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Tel Aviv, 64239, Israel
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Brescia, 25123, Italy
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Catania, 95126, Italy
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Florence, 50134, Italy
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Lecco, 23900, Italy
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Milan, 20133, Italy
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Milan, 20141, Italy
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Milan, 20159, Italy
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Milan, 20162, Italy
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Naples, 80131, Italy
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Parma, 43126, Italy
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Pisa, 56126, Italy
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Roma, 00161, Italy
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Roma, 00168, Italy
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Torino, 10100, Italy
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Akashi-shi, 673-8558, Japan
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Chūōku, 104-0045, Japan
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Hidaka-shi, 350-1298, Japan
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Kashiwa, 227-8577, Japan
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Kobe, 650-0047, Japan
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Kōtoku, 135-8550, Japan
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Kurume-shi, 830-0011, Japan
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Nagoya, 464-8681, Japan
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Niigata, 951-8566, Japan
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Okayama, 700-8558, Japan
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Osaka, 541-8567, Japan
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Sagamihara-shi, 252-0375, Japan
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Sapporo, 003-0804, Japan
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Sendai, 980-8574, Japan
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Shinjuku-ku, 160-0023, Japan
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Shinjuku-ku, 160-8582, Japan
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Shiwa-gun, 028-3694, Japan
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Sunto-gun, 411-8777, Japan
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Toon-Shi, 791-0295, Japan
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Tsu, 514-8507, Japan
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Busan, 49241, South Korea
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Daegu, 42601, South Korea
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Goyang-si, 10408, South Korea
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Seongnam-si, 13620, South Korea
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Seoul, 03080, South Korea
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Seoul, 03722, South Korea
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Seoul, 06273, South Korea
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Seoul, 06351, South Korea
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Seoul, 08308, South Korea
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Seoul, 5505, South Korea
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Suwon, 16499, South Korea
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Yangsan, 50612, South Korea
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A Coruña, 15006, Spain
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Badalona, 08916, Spain
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Barcelona, 08036, Spain
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Córdoba, 14004, Spain
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Donostia / San Sebastian, 20014, Spain
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Girona, 17007, Spain
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L'Hospitalet de Llobregat, 08908, Spain
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Madrid, 28034, Spain
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Madrid, 28041, Spain
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Valencia, 46010, Spain
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Linköping, 581 85, Sweden
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Lund, 22242, Sweden
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Solna, 171 64, Sweden
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Umeå, 90737, Sweden
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Uppsala, 751 85, Sweden
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Basel, 4031, Switzerland
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Münsterlingen, 8596, Switzerland
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Sankt Gallen, 9007, Switzerland
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Thun, 3600, Switzerland
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Zollikerberg, CH-8125, Switzerland
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Zurich, 8091, Switzerland
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Changhua, Taiwan
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New Taipei City, 220, Taiwan
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Taichung, 40447, Taiwan
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Taichung, 40705, Taiwan
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Tainan, 704, Taiwan
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Tainan, 73657, Taiwan
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Taipei, 100, Taiwan
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Taipei, 11259, Taiwan
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NOT_YET_RECRUITING

Taoyuan, 333, Taiwan
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NOT_YET_RECRUITING

Bangkok, 10210, Thailand
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NOT_YET_RECRUITING

Bangkok, 10400, Thailand
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RECRUITING

Bangkok, 10700, Thailand
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NOT_YET_RECRUITING

Chiang Mai, 50200, Thailand
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NOT_YET_RECRUITING

Dusit, 10300, Thailand
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Khon Kaen, 40002, Thailand
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Songkhla, 90110, Thailand
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RECRUITING

Barrow in Furness, LA14 4LF, United Kingdom
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Birmingham, B152GW, United Kingdom
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NOT_YET_RECRUITING

Cambridge, CB2 0QQ, United Kingdom
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NOT_YET_RECRUITING

Canterbury, CT1 3NG, United Kingdom
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NOT_YET_RECRUITING

Cardiff, CF15 7QZ, United Kingdom
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Edinburgh, EH4 2XU, United Kingdom
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Greater London, SW3 6JJ, United Kingdom
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London, EC1A 7BE, United Kingdom
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NOT_YET_RECRUITING

London, SE1 9RT, United Kingdom
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Nottingham, NG5 1PB, United Kingdom
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Sutton, SM2 5PT, United Kingdom
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Swansea, SA12 7BR, United Kingdom

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