New hope for hard-to-treat ovarian cancer: targeted drug enters phase 2 trial

NCT ID NCT06690775

Recruiting now Disease control Sponsor: TORL Biotherapeutics, LLC Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests a new drug called TORL-1-23 in women with advanced ovarian cancer that no longer responds to platinum-based chemotherapy. The drug targets a protein called claudin 6 found on cancer cells. About 230 women will receive the drug to see if it shrinks tumors and how safe it is.

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Conditions

The condition(s) this trial relates to.

Carcinoma, Ovarian Epithelial fallopian tube cancer fallopian tube neoplasm ovarian carcinoma ovarian endometrioid adenocarcinoma primary peritoneal carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ENDOMETRIOID OVARIAN CANCER EPITHELIAL OVARIAN CANCER FALLOPIAN TUBE CANCER PRIMARY PERITONEAL

Contacts and locations

Locations

Antwerp University Hospital (UZA)
RECRUITING

Edegem, Antwerp, 2650, Belgium
Asan Medical Center
RECRUITING

Seoul, Songpa-Gu, 05505, South Korea
BC Cancer - Abbotsford
RECRUITING

Abbotsford British Columbia, British Columbia, V2S 0C2, Canada
Blacktown Hospital
RECRUITING

Blacktown, New South Wales, 2148, Australia
British Columbia Cancer Agency (BC Cancer, part of the Provincial Health Services Authority)
RECRUITING

Vancouver, British Columbia, V5Z 4E6, Canada
CHU Liège
RECRUITING

Liège, Wallonia, B-4000, Belgium
Centre Hospitalier de l'Universite de Montreal (CHUM)
RECRUITING

Montreal, Quebec, H2X 0C2, Canada
Centre Leon Berard
RECRUITING

Lyon, Auvergne- Rhôn-Alpes, 69008, France
Charité Universitätsmedizin Berlin
RECRUITING

Berlin, State of Berlin, 13353, Germany
City of Hope National Medical Center
RECRUITING

Duarte, California, 91010, United States
Cliniques Universitaires Saint-Luc
RECRUITING

Woluwe-Saint-Lambert, Brussels Capital, 1200, Belgium
Curie Oncology (Farrer)
RECRUITING

Singapore, Singapore, 217562, Singapore
Duke Cancer Center
RECRUITING

Durham, North Carolina, 27710, United States
Flinders Medical Centre
RECRUITING

Bedford Park, South Australia, 5042, Australia
Fondazione Policlinico Universitario A. Gemelli IRCCS
RECRUITING

Rome, Rome, 00168, Italy
Hospital Maisonneuve Rosemont
RECRUITING

Montreal, Quebec, H1T 2M4, Canada
Humanitas San Pio X
RECRUITING

Milan, Milano, 20159, Italy
IRCCS Giovani Paolo II - Instituto Oncologico
RECRUITING

Bari, Apulia, 70124, Italy
Icon Cancer Centre Chermside
RECRUITING

Chermside, Queensland, QLD 4032, Australia
Institut Catalá d'Oncologia de Girona
RECRUITING

Girona, Catalonia, 17007, Spain
Institut Gustave Roussy
RECRUITING

Villejuif, Île-de-France Region, 94805, France
Institut de Cancérologie de l'Ouest
RECRUITING

Saint-Herblain, Pays de la Loire Region, 44805, France
Linear Clinical Research
RECRUITING

Perth, Western Australia, WA 6009, Australia
Massachusetts General Hospital
RECRUITING

Boston, Massachusetts, 02114, United States
Mayo Clinic
RECRUITING

Rochester, Minnesota, 55905, United States
Mayo Clinic Florida
RECRUITING

Jacksonville, Florida, 32224, United States
Mayo Clinic Hospital
RECRUITING

Phoenix, Arizona, 85054, United States
McGill University Health Centre (MUHC) - Royal Victoria Hospital
RECRUITING

Montreal, Quebec, H4A 3J1, Canada
Medizinische Universitat Landeskrankenhaus Graz
RECRUITING

Graz, Styria, 8036, Austria
Monash Medical Centre
RECRUITING

Clayton, Melbourne, VIC 3168, Australia
National Cancer Centre
RECRUITING

Singapore, Singapore, 168583, Singapore
National University Cancer Institute
RECRUITING

Singapore, Singapore, 119074, Singapore
Nuovo Ospedale di Prato S Stefano
RECRUITING

Prato, Prato, 59100, Italy
Ordensklinikum Linz
RECRUITING

Linz, Upper Austria, 4010, Austria
Princess Margaret Cancer Centre - University Health Network (UHN)
RECRUITING

Toronto, Ontario, M5G 2M9, Canada
Providence St. Jude Medical Center
RECRUITING

Fullerton, California, 92835, United States
Rutgers Cancer Institute
RECRUITING

New Brunswick, New Jersey, 08901, United States
SCRI - Alliance Cancer Specialists, PC
RECRUITING

Doylestown, Pennsylvania, 18901, United States
SCRI - Arizona Oncology Associates, PC-HOPE
RECRUITING

Tucson, Arizona, 85711, United States
SCRI - Maryland Oncology Hematology, P.A.
RECRUITING

Annapolis, Maryland, 21401, United States
SCRI - Minnesota Oncology Hematology, P.A.
RECRUITING

Minneapolis, Minnesota, 55404, United States
SCRI - Northwest Cancer Specialists, P.C.
RECRUITING

Portland, Oregon, 97227, United States
SCRI - Sansum Clinic
RECRUITING

Santa Barbara, California, 93105, United States
SCRI - Texas Oncology
RECRUITING

Fort Worth, Texas, 76104, United States
SCRI - Virginia Oncology Associates
RECRUITING

Norfolk, Virginia, 23502, United States
Seoul National University Hospital
RECRUITING

Seoul, Gwanak-gu, 03080, South Korea
Sir Mortimer B. Davis Jewish General Hospital
RECRUITING

Montreal, Quebec, H3T 1E2, Canada
Smilow Cancer Hospital at Yale - New Haven
RECRUITING

New Haven, Connecticut, 06510, United States
St. James Hospital
RECRUITING

Dublin, Leinster, DO8C9X2, Ireland
Stanford Cancer Center
RECRUITING

Palo Alto, California, 94304, United States
Start Dublin - Mater Misericordiae University Hospital
RECRUITING

Dublin, Leinster, D07 R2WY, Ireland
Stephenson Cancer Center at the University of Oklahoma
RECRUITING

Oklahoma City, Oklahoma, 73104, United States
Sunnybrook Research Institute
RECRUITING

Toronto, Ontario, M4N 3M5, Canada
The Catholic University of Korea, Seoul St. Mary's Hospital
RECRUITING

Seoul, Seocho-Gu, 06591, South Korea
The James Cancer Hospital and Solove Research Institute - Ohio State University
RECRUITING

Columbus, Ohio, 43210, United States
UCLA - JCCC Clinical Research Unit
RECRUITING

Los Angeles, California, 90095, United States
UZ Leuven
RECRUITING

Leuven, Flemish Brabant, 3000, Belgium
Universitatsklinik Innsbruck
RECRUITING

Innsbruck, Tyrol, 6020, Austria
Universitatsklinikum Heidelberg
RECRUITING

Heidelberg, Baden-Wurttenberg, 69120, Germany
University of Chicago Medical Center
RECRUITING

Chicago, Illinois, 60637, United States
University of Minnesota
RECRUITING

Minneapolis, Minnesota, 55404, United States
University of Pennsylvania
RECRUITING

Philadelphia, Pennsylvania, 19104-4238, United States
Universitätsklinikum Erlangen
RECRUITING

Erlangen, Bavaria, 91054, Germany
Washington University
RECRUITING

St Louis, Missouri, 63108, United States
Winship Cancer Institute, Emory University
RECRUITING

Atlanta, Georgia, 30322, United States
Yonsei University Health System, Severance Hospital
RECRUITING

Seoul, Seodaemun-Gu, 03722, South Korea

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