Promising combo tackles rare sarcomas in early trial

NCT ID NCT03123276

First seen Feb 21, 2026 · Last updated May 15, 2026 · Updated 6 times

Summary

This early-phase study tested a combination of two drugs—pembrolizumab (an immunotherapy) and gemcitabine (a chemotherapy)—in 25 people with rare soft tissue sarcomas (leiomyosarcoma or undifferentiated pleomorphic sarcoma) that had spread or couldn't be removed. The main goal was to find a safe dose and see how well the treatment worked. While the approach aims to control the disease, it is not a cure, and ongoing management is expected.

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Contacts and locations

Locations

  • Royal Marsden

    London, United Kingdom

Conditions

Explore the condition pages connected to this study.