Royal Marsden Nhs Foundation Trust

This early-phase study tests two drugs, palbociclib and avelumab, together for people with a specific type of advanced breast cancer (AR+ triple-negative). The main goals are to find the safest doses and see if the combination can shrink tumors. About 45 participants with advance…

This study is for men with intermediate-risk prostate cancer. It compares standard radiation given in two sessions to a lower-dose version, both using advanced MRI-guided technology. The goal is to see if the lower dose causes fewer urinary side effects while still controlling th…

This study tests a digital exercise program designed to help prostate cancer patients on hormone therapy stick with physical activity. Side effects like weight gain, muscle loss, and fatigue are common, and exercise can help, but many patients struggle to keep it up. The trial wi…

This study looks at tissue and imaging data from 800 people with high-risk soft tissue sarcoma to find ways to personalize chemotherapy. Participants either have surgery alone or chemo before surgery. The goal is to build a tumor atlas and a tool to predict who benefits from chem…

This study follows 200 adults with solid tumors who are starting immunotherapy (checkpoint inhibitors). Researchers collect blood and tissue samples before and during treatment to understand why some patients develop immune-related side effects. The goal is to find early warning …