New study tracks outcomes of Second-Chance surgery for head and neck cancer

NCT ID NCT05808920

Recruiting now Knowledge-focused Sponsor: Royal Marsden NHS Foundation Trust Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

The RESCUE study is looking at 400 adults who have salvage surgery for head and neck cancer that came back after radiation. Researchers will track how long patients live without the cancer returning and how well they function after surgery. They will also analyze tumor tissue, blood, and saliva to explore links between genetics, past radiation, and cancer recurrence.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If successful, this study could help doctors better predict which patients benefit from salvage surgery and understand why cancer returns after radiotherapy.
What could go wrong: This is an observational study, not a treatment trial. It will not directly test a new therapy, and results may not change current care for years.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

head and neck cancer Head and Neck Neoplasms head and neck squamous cell carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HEAD AND NECK CANCER

Contacts and locations

Locations

Aintree Hospital
RECRUITING

Liverpool, United Kingdom
Head and Neck Unit, Royal Marsden Hospital
RECRUITING

London, SW3 6JJ, United Kingdom
NHS Lothian
RECRUITING

Edinburgh, United Kingdom
Northwick Park
RECRUITING

London, United Kingdom
Oxford University Hospital NHS Foundation Trust
RECRUITING

Oxford, United Kingdom
Poole Hospital, University Hospitals Dorset
RECRUITING

Poole, United Kingdom
South Tyneside and Sunderland NHS Foundation Trust
COMPLETED

Sunderland, United Kingdom
University Hospitals Derby and Burton
RECRUITING

Derby, United Kingdom
Western General, Greater Glasgow and Clyde
RECRUITING

Glasgow, United Kingdom

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