Royal Marsden Nhs Foundation Trust

This early-stage study tests two drugs, palbociclib and avelumab, together for people with a specific type of advanced breast cancer (AR+ triple negative). The main goals are to find the safest doses and see if the combination can shrink tumors. About 45 participants will take pa…

This study is testing whether giving a lower dose of radiation in just two sessions can reduce side effects for men with intermediate-risk prostate cancer. All participants will be treated on a special MRI-guided machine (MR-Linac) that adapts the radiation daily. The main goal i…

This study tests whether a digital exercise program with online group sessions can help prostate cancer patients on hormone therapy exercise more regularly. 160 participants will either get standard care or standard care plus the digital program. Adherence is tracked with a weara…

This study explores whether a blood test that detects circulating tumor DNA (ctDNA) can help doctors personalize treatment for people with five types of advanced cancer: non-small cell lung cancer, gastrointestinal stromal tumors, colorectal cancer, biliary tract cancer, and ovar…

This study is for 500 adults with non-metastatic breast cancer who are about to start treatment like chemotherapy or targeted therapy before surgery. Researchers will collect tumor tissue, blood, and sometimes stool samples and MRI scans during treatment. The goal is to learn why…

This study looks at whether it is possible to take multiple tissue samples (biopsies) from different tumor sites in people with metastatic breast cancer at different times during treatment. The goal is to learn how cancers change and become resistant to therapy. About 200 adults …

This study is collecting tissue samples and medical data from 800 high-risk sarcoma patients to develop personalized treatment approaches. Researchers will analyze genetic and protein profiles to better predict which patients benefit from chemotherapy before surgery. The goal is …

The RESCUE study is looking at 400 adults who have salvage surgery for head and neck cancer that came back after radiation. Researchers will track how long patients live without the cancer returning and how well they function after surgery. They will also analyze tumor tissue, bl…

This study looks at how head and neck cancer cells change after radiation treatment. Researchers will collect tissue and blood samples from 20 adults who had radiation before and are now having robotic surgery for new or returning tumors. The goal is to understand why some cancer…

This study follows 200 cancer patients starting immunotherapy (checkpoint inhibitors) to understand why some develop immune-related side effects. Researchers will collect blood samples and clinical data to find early warning signs. The goal is to improve how doctors monitor and m…