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Could less radiation be better for prostate cancer?

NCT ID NCT06638541

Recruiting now Symptom relief Sponsor: Royal Marsden NHS Foundation Trust Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study is testing whether giving a lower dose of radiation in just two sessions can reduce side effects for men with intermediate-risk prostate cancer. All participants will be treated on a special MRI-guided machine (MR-Linac) that adapts the radiation daily. The main goal is to see if the lower dose causes fewer urinary problems while still keeping the cancer under control.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
radiation therapy
What this could lead to
If successful, this could show that a lower radiation dose is just as effective but causes fewer urinary side effects for men with intermediate-risk prostate cancer.
What could go wrong
This is a small, early-phase trial with only 54 participants, so results may not apply to all patients. Lowering the dose might also reduce cancer control, though the study will monitor PSA levels closely.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

prostate adenocarcinoma prostate cancer

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PROSTATE CANCER

Contacts and locations

Study contacts

  • Contact

    Email: •••••@•••••

Locations

  • Sunnybrook Health Sciences Centre

    NOT_YET_RECRUITING

    Toronto, Canada

  • The Christie NHS Foundation Trust

    RECRUITING

    Manchester, M20 4BX, United Kingdom

  • The Royal Marsden NHS Foundation Trust

    RECRUITING

    Sutton, United Kingdom

    Contact Email: •••••@•••••

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