Aspirin vs. heparin: which prevents clots better after cancer bone surgery?
NCT ID NCT03244020
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study compares two common blood thinners—aspirin and enoxaparin (Lovenox)—to see which works better at preventing dangerous blood clots after surgery for bone cancer or cancer that has spread to the bone. About 2,868 adults having pelvic or leg surgery for these conditions will be assigned to take one of the two drugs daily for four weeks. The goal is to find out which drug reduces clots more while causing fewer side effects like bleeding.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Aspirin and enoxaparin (a blood thinner)
What this could lead to
If this trial succeeds, it could show that aspirin is as effective as enoxaparin for preventing blood clots after cancer-related orthopedic surgery, potentially reducing bleeding risks and simplifying treatment.
What could go wrong
This is a Phase 4 trial, but it is still enrolling and results may not apply to all patients. There is a risk of bleeding or hematoma with both drugs, and the study may not find a clear difference between them.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Beth Israel Deaconess Medical Center
Boston, Massachusetts, 02215, United States
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Brigham and Women's Hospital
Boston, Massachusetts, 02115, United States
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Cleveland Clinic
Cleveland, Ohio, 44195, United States
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Cooper University Health Care
Camden, New Jersey, 08103, United States
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Johns Hopkins University
Baltimore, Maryland, 21287, United States
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Louisiana State University Health
New Orleans, Louisiana, 70112, United States
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Moffitt Cancer Center
Tampa, Florida, 33612, United States
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Santiago Lozano-Calderon
Boston, Massachusetts, 02114, United States
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University of California Los Angeles Health
Los Angeles, California, 90404, United States
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University of Missouri-Columbia Cancer Care
Columbia, Missouri, 65201, United States