Aspirin vs. heparin: which prevents clots better after cancer bone surgery?

NCT ID NCT03244020

ENROLLING_BY_INVITATION Disease control Sponsor: Massachusetts General Hospital Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study compares two common blood thinners—aspirin and enoxaparin (Lovenox)—to see which works better at preventing dangerous blood clots after surgery for bone cancer or cancer that has spread to the bone. About 2,868 adults having pelvic or leg surgery for these conditions will be assigned to take one of the two drugs daily for four weeks. The goal is to find out which drug reduces clots more while causing fewer side effects like bleeding.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Aspirin and enoxaparin (a blood thinner)
What this could lead to: If this trial succeeds, it could show that aspirin is as effective as enoxaparin for preventing blood clots after cancer-related orthopedic surgery, potentially reducing bleeding risks and simplifying treatment.
What could go wrong: This is a Phase 4 trial, but it is still enrolling and results may not apply to all patients. There is a risk of bleeding or hematoma with both drugs, and the study may not find a clear difference between them.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

bone cancer bone sarcoma Hematoma metastatic carcinoma in the bone sarcoma soft tissue sarcoma venous thromboembolism

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ANTICOAGULANT-INDUCED BLEEDING BONE METASTASES BONE SARCOMA HEMATOMA SARCOMA SOFT TISSUE SARCOMA VENOUS THROMBOEMBOLISM

Contacts and locations

Locations

Beth Israel Deaconess Medical Center

Boston, Massachusetts, 02215, United States
Brigham and Women's Hospital

Boston, Massachusetts, 02115, United States
Cleveland Clinic

Cleveland, Ohio, 44195, United States
Cooper University Health Care

Camden, New Jersey, 08103, United States
Johns Hopkins University

Baltimore, Maryland, 21287, United States
Louisiana State University Health

New Orleans, Louisiana, 70112, United States
Moffitt Cancer Center

Tampa, Florida, 33612, United States
Santiago Lozano-Calderon

Boston, Massachusetts, 02114, United States
University of California Los Angeles Health

Los Angeles, California, 90404, United States
University of Missouri-Columbia Cancer Care

Columbia, Missouri, 65201, United States

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