BONE SARCOMA

This study is testing if taking a drug called regorafenib for up to a year can help prevent bone cancers (sarcomas) from returning after patients finish their initial chemotherapy and surgery. It will compare patients who take the drug to those who receive standard monitoring wit…

This is a first-in-human study testing a new type of engineered immune cell therapy for patients with advanced soft tissue or bone sarcoma. The main goals are to find a safe dose and see if the treatment can help control the disease. The trial will enroll about 40 patients who ha…

This study aims to understand how well patients recover function and how their bones heal after surgery to remove bone tumors. Researchers will follow 300 patients for three years after their reconstructive surgery, which may use bone grafts or artificial devices. The goal is to …

This study is testing if a drug called regorafenib can help control aggressive bone cancers like osteosarcoma when standard treatments haven't fully eliminated the disease. It will involve 36 patients aged 12 and older who still have detectable cancer after their initial therapy.…

This early-stage study is testing a new technique called In Vivo Lung Perfusion (IVLP) for people with bone or soft tissue sarcoma that has spread to both lungs. During surgery to remove visible tumors, doctors will deliver chemotherapy directly to one lung for 3 hours to try to …

This study is testing if a special fluorescent dye can help surgeons see tumor edges better during sarcoma removal surgery. The dye is injected before the operation and glows under a special camera, potentially helping the surgeon leave less cancerous tissue behind. Researchers w…

This study compares three different approaches for treating pelvic bone cancers (sarcomas) to see which one works best. Researchers are testing carbon ion radiation therapy against traditional surgery and proton radiation therapy. They want to find out which treatment gives patie…

This study aims to understand how patients recover physically and mentally after limb-saving surgery for bone or soft tissue sarcoma in the leg. Researchers will observe 60 adult survivors, focusing on their walking patterns, physical function, and overall quality of life. The go…