BONE SARCOMA

This study tests whether the drug regorafenib, taken for up to 12 months, can help control high-grade bone sarcomas (like osteosarcoma) that didn't fully respond to standard treatment. About 36 participants aged 12 and older will receive regorafenib plus supportive care. The goal…

This early-phase study tests a technique called in vivo lung perfusion (IVLP), where chemotherapy is delivered directly into one lung during surgery to remove sarcoma tumors that have spread there. The goal is to kill any remaining microscopic cancer cells while reducing side eff…

This early-phase trial tests a new treatment called attIL12 T-cell therapy for people with advanced soft tissue or bone sarcoma that has spread. The therapy uses the patient's own immune cells, modified to attack the cancer. The main goal is to find a safe dose and see if it can …

This study compares carbon ion therapy, surgery, and proton therapy for people with pelvic bone sarcomas (a type of cancer). The goal is to see which treatment provides better disease control and fewer side effects, and to measure quality of life after treatment. About 72 partici…

This study tests whether taking regorafenib for up to 12 months after initial treatment can delay or prevent bone sarcoma from coming back. About 168 patients with various bone sarcomas will be randomly assigned to receive the drug or just be monitored. The goal is to see if the …

This study looks at whether giving sarcoma patients early access to mental healthcare before and after surgery can help reduce depression and anxiety. About 60 adults with bone or soft tissue sarcoma will be randomly assigned to get either early psychiatric support or usual care.…

This study tests whether a dye injected during surgery can help surgeons see if they have removed all of a sarcoma tumor. About 50 adults with bone or soft tissue sarcoma will take part. The dye's accuracy will be compared to standard lab tests on the removed tissue.

This study follows 300 people who had surgery to remove bone tumors and then had reconstruction using bone grafts or artificial parts. Researchers will measure how well the bone heals and how much function patients regain over 3 years. The goal is to better understand recovery af…

This study looks at how people who had limb-saving surgery for bone or soft tissue sarcoma in their leg are doing physically and emotionally. Researchers will use surveys and walking tests to measure function, pain, and quality of life. The goal is to learn more about recovery an…