Engineered immune cells take on Hard-to-Treat cancers
NCT ID NCT06942143
First seen Jun 26, 2026 · Last updated Jun 26, 2026
Summary
This early-phase trial tests a new cell therapy called Super1 TCR-T in 15 people with advanced solid tumors (sarcoma, lung cancer, or melanoma) that have not responded to first-line treatment. The therapy involves taking a patient's own immune cells, genetically modifying them to better recognize and attack cancer cells, and infusing them back after a short course of chemotherapy. The main goals are to check safety and find the right dose.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Super1 TCR-T cells (genetically modified immune cells)
- What this could lead to
- If successful, this could point toward a new treatment option for certain advanced solid tumors that have not responded to standard therapy.
- What could go wrong
- This is a very early, small Phase 1 trial focused on safety, not effectiveness. The treatment may not shrink tumors or improve survival, and there are risks from the cell infusion and pre-conditioning chemotherapy.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Sun Yat-sen University Cancer Center
RECRUITINGGuangzhou, Gaungdong, 510700, China
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Other studies related to the condition(s) this trial covers.
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