New combo targets sarcoma in limbs

NCT ID NCT04332874

Recruiting now Disease control Sponsor: Memorial Sloan Kettering Cancer Center Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether combining the immunotherapy drug pembrolizumab with chemotherapy drugs (melphalan and dactinomycin) delivered directly to the affected limb via isolated limb infusion can safely delay cancer growth. It enrolls 30 patients aged 12 and older with advanced sarcoma in an arm or leg. The goal is to see if the disease stays stable for at least 6 months.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: pembrolizumab, melphalan, dactinomycin
What this could lead to: If successful, this combination could delay cancer progression in the affected limb, offering a new option for patients with advanced sarcoma.
What could go wrong: This is a small, early-phase trial (30 participants) focused on safety and progression delay, not a cure. Side effects from chemotherapy and immunotherapy may occur.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

alveolar soft part sarcoma dermatofibrosarcoma protuberans myxofibrosarcoma sarcoma undifferentiated pleomorphic sarcoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ALVEOLAR SOFT PART SARCOMA MYXOFIBROSARCOMA SARCOMA UNDIFFERENTIATED PLEOMORPHIC SARCOMA

Contacts and locations

Locations

Memorial Sloan Kettering Basking Ridge (Limited protocol activities)
RECRUITING

Basking Ridge, New Jersey, 07920, United States
Memorial Sloan Kettering Bergen (Limited Protocol Activities)
RECRUITING

Montvale, New Jersey, 07645, United States
Memorial Sloan Kettering Cancer Center
RECRUITING

New York, New York, 10065, United States
Memorial Sloan Kettering Cancer Center @ Suffolk - Commack (Limited Protocol Activities)
RECRUITING

Commack, New York, 11725, United States
Memorial Sloan Kettering Monmouth (Limited protocol activities)
RECRUITING

Middletown, New Jersey, 07748, United States
Memorial Sloan Kettering Nassau (Limited Protocol Activities)
RECRUITING

Uniondale, New York, 11553, United States
Memorial Sloan Kettering Westchester (Limited Protocol Activities)
RECRUITING

Harrison, New York, 10604, United States

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