Engineered t cells take on childhood liver cancer in first human test
NCT ID NCT02932956
First seen Jun 26, 2026 · Last updated Jun 26, 2026
Summary
This early-phase trial tests a new experimental treatment called GAP T cells in children and young adults with liver cancer that has come back or not responded to standard therapy. The cells are made from the patient's own immune T cells, which are genetically modified to recognize and attack a protein (GPC3) found on the cancer cells. The main goals are to find a safe dose and to see how long the cells last in the body.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
GAP T cells (genetically modified immune cells) plus chemotherapy (cyclophosphamide and fludarabine)
What this could lead to
If it works, this could point toward a new treatment option for children with hard-to-treat liver cancer.
What could go wrong
This is a very early, small Phase 1 trial (only 10 participants) focused on safety, not effectiveness. The cells may not last or control the cancer, and side effects like cytokine release syndrome are possible.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Texas Children's Hospital
Houston, Texas, 77030, United States