Engineered immune cells take aim at tough leukemia
NCT ID NCT04219163
First seen Jun 24, 2026 · Last updated Jun 26, 2026 · Updated 1 time
Summary
This early-phase trial tests a new type of cell therapy for adults with acute myeloid leukemia (AML) that has returned or not responded to standard treatment. The therapy uses the patient's own T cells, which are modified in the lab to recognize and attack leukemia cells carrying a protein called CLL-1. The study aims to find a safe dose and see if the cells can shrink the cancer, with the ultimate goal of getting patients well enough for a stem cell transplant.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
CLL-1 CAR T-cells (a type of immune cell therapy)
What this could lead to
If successful, this could lead to a new treatment option for patients with hard-to-treat acute myeloid leukemia, potentially helping them achieve remission before a stem cell transplant.
What could go wrong
This is a very early Phase 1 trial with only 18 participants, so it is too small to prove effectiveness. The therapy may cause severe side effects, and it is not yet known if the cells will last long enough to control the cancer.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Texas Children's Hospital
Houston, Texas, 77030, United States