Baylor College Of Medicine

This study tests whether giving a higher dose of albumin (a protein) to people with advanced liver cirrhosis and fluid buildup (ascites) can reduce the need for fluid drainage procedures and prevent complications. About 100 adults with hard-to-treat ascites will receive either hi…

This study tests a program called OPTIMISE that helps cancer patients manage other chronic conditions like diabetes or high blood pressure during treatment. It assigns a nurse navigator to improve communication between cancer doctors and primary care doctors. About 340 patients w…

This early-phase trial tests a new type of immune cell therapy for patients with EBV-positive Hodgkin or non-Hodgkin lymphoma that has returned or not responded to standard treatments. The researchers add a gene called C7R to the patient's own T cells to help them survive longer …

This early-phase study tests a new approach for patients with certain lymphomas (Hodgkin, NK/T-cell, and others) that have returned or not responded to treatment. The therapy uses immune cells from healthy donors that are specially trained in the lab to attack cancer cells carryi…

This early-phase study tests whether specially trained immune cells from healthy donors can safely treat viral infections (EBV, CMV, adenovirus, BK virus) in patients who have had a stem cell transplant or certain CAR-T therapy. These infections can be life-threatening when the i…

This early-phase study tests a new treatment for people with Hodgkin or non-Hodgkin lymphoma that has returned or not responded to standard therapy. The treatment uses the patient's own T cells, which are genetically modified to recognize and attack cancer cells carrying the CD30…

This study tests whether walking at least 10,000 steps a day and avoiding snacks after 8 p.m. can improve metabolic health in teenagers aged 12-18 with prediabetes. Eighty participants will be randomly assigned to either the lifestyle program or standard care for 8 weeks. The mai…

This early-phase study tests a new treatment for people with T-cell leukemia or lymphoma that has come back. The treatment uses specially trained immune cells from a healthy donor, designed to recognize and attack cancer cells carrying a marker called CD7. The goal is to see if t…

This study tests whether growth hormone replacement therapy is safe and effective for veterans with Gulf War Illness who also have a growth hormone deficiency. Twenty veterans will receive the hormone for six months, and researchers will measure changes in belly fat, symptoms, an…

This early-phase trial tests a new type of immune therapy for people with certain aggressive brain tumors, including DIPG and high-grade glioma. The treatment uses the patient's own T cells, which are modified in the lab to recognize a protein called GD2 on cancer cells and to pr…

This trial tests a new fetal surgery to repair complex gastroschisis, a birth defect where the baby's intestines stick out of the belly. Ten pregnant women will undergo a fetoscopic procedure to reduce the bowel and close the skin. The goal is to see if this approach is safe and …

This early-phase trial tests a new approach for people with certain lymphomas that have come back or not responded to treatment. Researchers take immune cells from healthy donors, modify them to recognize and attack CD30-positive cancer cells, and add a molecule (C7R) to boost th…

This study looks at whether a special treatment plan for children with acute myeloid leukemia (AML) can work well in Malawi, where resources are limited. About 30 children under 18 will receive a treatment guideline designed to balance curing the disease with manageable side effe…

This early-phase trial tests a new immunotherapy called CARE T cells in children and young adults with solid tumors that have returned or not responded to standard treatment. The cells are taken from the patient, genetically modified to recognize a protein (GPC3) found on many so…

This study tests a new device called the Pathfinder rigidizing overtube, which stiffens during colon polyp removal to give doctors better control. Researchers will compare it to the standard procedure in 66 adults with colon growths. The goal is to see if it makes the surgery fas…

This study tests a program called 'Type 1 Doing Well' for youth aged 10–13 with type 1 diabetes and their parents. The program uses a smartphone app, goal-setting, and family meetings to build on the teen's diabetes strengths. Researchers want to see if it improves blood sugar co…

This study tests a new way to make immune cells (called GRALE T cells) that are trained to attack cells infected with the Epstein-Barr virus (EBV), which is linked to some lymphomas. The trial includes people with Hodgkin or non-Hodgkin lymphoma, or related diseases, whose cancer…

This early-stage trial tests whether specially trained immune cells can safely target and attack multiple myeloma, as well as its early forms MGUS and smoldering myeloma. Up to 36 participants will receive two infusions of their own T cells that have been engineered to recognize …

This early-stage trial tests a new combination treatment for people with advanced HER2-positive solid tumors (like breast, lung, or stomach cancer). Participants receive an injection of a special virus directly into one tumor to help the immune system attack cancer, followed by a…

This early-stage trial tests a new type of immunotherapy for recurrent glioblastoma, an aggressive brain cancer. Researchers take a patient's own T cells and genetically engineer them to recognize and attack cancer cells that carry a protein called GPC3. The cells also include a …

This study tests whether a new type of immune cell therapy (HER2-CAR T cells) combined with drugs that boost the immune system (pembrolizumab or nivolumab) is safe for people with advanced sarcoma. About 25 participants will receive chemotherapy before the cell infusion to help t…

This study is testing a special stent-graft device to repair complex aneurysms in the aorta, the body's main artery. The device is inserted through leg arteries, avoiding open surgery. Researchers will track safety, survival, and quality of life in 760 people over time. The goal …

This study tests a new treatment for people with advanced B-cell lymphoma or leukemia that has returned or not improved after standard therapy. Researchers take a patient's own T-cells, add a special receptor (CAR) that targets the CD19 protein on cancer cells, and also add extra…

This study is for people who need a stem cell transplant but only have a half-matched donor, like a parent or child. Researchers are using a machine to pick out only the CD34+ stem cells from the donor's blood, removing the T cells that can cause a serious complication called gra…

This study tests a step-by-step treatment plan for fetuses with lower urinary tract obstruction (LUTO), a condition where a blockage prevents urine from leaving the bladder. Doctors will use either a shunt to drain urine or a tiny scope to clear the blockage. The goal is to see i…

This Phase 1 trial is testing a new type of immunotherapy for children and young adults with B-cell acute lymphoblastic leukemia (B-ALL) that has come back or not gone away. The treatment uses the patient's own T cells, which are modified in the lab to recognize and attack leukem…

This early-phase trial tests a new type of immunotherapy for adults with solid tumors that have a protein called GPC3 on their surface. Researchers take a patient's own T cells, add genes to help them recognize and attack GPC3-positive cancer cells, and also include a safety swit…

This study tests a newer heart pacing method (His or left bundle branch pacing) against the standard method (biventricular pacing) in over 2,000 adults with heart failure and a weak heart pump. The goal is to see which approach better improves quality of life, reduces hospital st…

This study tests whether giving immunotherapy drugs (durvalumab and tremelimumab) alone or with chemotherapy before surgery can help prevent pleural mesothelioma from coming back. About 52 people with potentially removable tumors will take part. The main goal is to see if more th…

This early-stage trial tests a new approach for children with neuroblastoma that has come back or not responded to standard treatment. Researchers take the child's own natural killer T cells, add genes to help them recognize and attack neuroblastoma cells, and give them back alon…

This phase 3 trial compares two chemotherapy approaches for children and young adults with Langerhans cell histiocytosis (LCH), a rare cancer that can damage tissues. One group gets the standard two-drug combo (vinblastine/prednisone), while the other gets a single drug called cy…

This early-phase trial is testing a new type of immunotherapy for people with T-cell leukemia or lymphoma that has returned. The treatment involves taking a patient's own immune cells (or cells from a past stem cell donor), adding a special receptor that targets a protein called …

This study tests a portable microscope with artificial intelligence to help doctors spot early signs of esophageal cancer during a routine scope exam. Researchers will enroll 200 adults in Brazil and the United States who are already scheduled for screening. The goal is to see if…

This study offers rapid whole genome sequencing and virtual genetic consultations to 200 seriously ill newborns in Texas hospitals with limited resources, especially along the Texas-Mexico border. Researchers want to see if the virtual tool, Consultagene, helps doctors diagnose r…

This study tests whether combining a food prescription program with education on healthy feeding practices can help parents prevent chronic diseases like obesity in their children. Researchers will enroll 375 parents of children aged 4-8 in Texas. Participants will receive either…

This pilot study tests whether applying a steroid cream to the foreskin for four weeks can prevent recurrent urinary tract infections (UTIs) in uncircumcised male infants under 6 months who have had their first fever-related UTI. Forty infants will receive either the steroid crea…

This study tests a mobile health app designed to help Hispanic adolescents (ages 12-18) who are overweight improve their diet, physical activity, and sleep. The goal is to see if the app can help prevent type 2 diabetes. The study will enroll 30 participants and last 30 days, foc…

This study looks at how safe and effective a new device, the Speedboat UltraSlim™, is when used for a surgery called POEM in people with achalasia or other throat muscle problems. The surgery is already standard care, and researchers will track symptom improvement and any side ef…

This study tests a new 3D-printed scoliosis brace that has flexible sections to improve comfort. Five teens aged 8-18 who already wear a standard brace will try the new brace and compare how it feels during everyday tasks like sitting and putting on shoes. The goal is to see if a…

This pilot study tests a combination of two non-invasive brain stimulation methods (iTBS and tDCS) in 20 veterans with mild-to-moderate Alzheimer's disease who also have mood swings, apathy, or agitation. Participants will receive one week of in-clinic iTBS sessions followed by f…

This study tests a non-invasive device that sends mild electrical pulses to the ear to stimulate the vagus nerve. Researchers want to see if it can improve attention and memory in 30 veterans with traumatic brain injury, depression, or PTSD. Participants will try both the real st…

This study aims to help families with food insecurity and mothers with depression by providing resources like food, rent help, and mental health support. Researchers will enroll 2,000 caregivers of young children in the hospital to see if these services improve mother-child bondi…

This study tests a coaching program called POSTCARE-O for women with ovarian cancer who have finished their initial treatment. The program provides support during the transition to survivorship, focusing on quality of life and emotional well-being. 120 women will be randomly assi…

This study compares two ways to remove abnormal growths from the colon: using a special traction device versus the standard method. The goal is to see if the device makes the procedure faster and reduces complications. About 150 adults with certain types of colon growths will tak…

This study tests a new device called the Speedboat™ Ultraslim, a bipolar radiofrequency knife, for removing precancerous growths in the esophagus. Researchers want to see if it works well and is safe compared to standard tools. The trial will involve 50 adults at two medical cent…

This study tests whether a short animated video and flyer, available in English and Spanish, can help patients collect cleaner urine samples. Contaminated samples often lead to wrong diagnoses and unnecessary antibiotics, which fuels antibiotic resistance. About 252 adults in pri…

This study is testing two different ways of delivering intensive cognitive behavioral therapy (CBT) to veterans with PTSD and anxiety disorders. One format is individual therapy over two weeks, and the other is group therapy over two days. Both are compared to standard care. The …

This study tests whether a guided therapy using psilocybin (the active ingredient in magic mushrooms) can safely help US Veterans with PTSD. Fifteen participants will receive two psilocybin sessions combined with talk therapy. The goal is to reduce PTSD symptoms and improve long-…

This study tests whether wearing special glasses that emit bright light can help reduce fatigue and improve thinking speed and attention in children and teens who have been treated for a brain tumor. The study will include 40 survivors and compare the bright light glasses to dim …

This observational study aims to find biological markers (biomarkers) for RAI1-related disorders, including Smith-Magenis and Potocki-Lupski syndromes. Researchers will study 90 participants through clinical exams, blood tests, optional skin biopsies, and sleep studies. The goal …

This study aims to understand how the light from tablet screens and the type of content children watch before bed affect their sleep, thinking skills, and emotions. Researchers will have 220 children aged 8 to 11 spend one hour before bed either using a bright tablet, a dim table…

This study aims to find the safest and most consistent dose of hookworm larvae to use in future vaccine trials. Healthy adults aged 18 to 45 will receive different numbers of hookworm larvae through the skin. Researchers will monitor side effects and measure hookworm eggs in stoo…

This study collects data from 500 children with severe, early-onset obesity to find genetic causes. Researchers will track how many kids have genetic variants linked to obesity and monitor changes in their BMI over time. The goal is to better understand the role of genetics in se…

This research study aims to learn more about children born with small or missing eyes (Microphthalmia, Anophthalmia, and Coloboma, or MAC) and how genetic changes may cause these conditions. Researchers will collect medical histories, saliva, and blood samples, and perform physic…

This study aims to find the specific gene that causes Aicardi syndrome, a rare brain disorder. Researchers will collect blood and skin samples from up to 500 patients and their parents to analyze their DNA. The goal is to identify genetic changes unique to people with Aicardi syn…

This study looks at how healthy substances called carotenoids (found in colorful fruits and vegetables) affect vision and skin in infants and toddlers. Researchers will track 208 healthy children from 4 to 24 months old, measuring their diet, skin carotenoid levels, and eyesight.…

This study tests a new wireless sensor called FlowSense, which is placed on the skin like a bandage to measure fluid flow in hydrocephalus patients with external drains. The goal is to see if it can accurately track drainage and pressure without needing X-rays or hospital equipme…

This study aims to better understand how brain activity relates to mood in people with depression or epilepsy. Researchers will record brain signals directly from electrodes placed inside the skull while participants complete mood assessments and tasks. The goal is to use explain…

This study looks at two common techniques surgeons use to enter the uterus during laser surgery for twin-to-twin transfusion syndrome. The goal is to see if one method causes less separation of the membrane around the baby. About 216 pregnant women with this condition will take p…

This study looks at how the body processes arginine, a natural nutrient, in teenagers with type 2 diabetes. Researchers will give participants arginine and measure its effect on insulin production. The goal is to better understand the disease and see if arginine could be a safe, …

This study aims to understand how the brain processes social and emotional information in people with treatment-resistant depression or epilepsy. Researchers will use special electrodes placed inside the brain to record activity while participants perform mood-related tasks. The …

This study offers genome sequencing to 25 newborns diagnosed with HIE (a severe brain condition from lack of oxygen at birth) who are receiving cooling therapy. Researchers want to find out how often genetic changes cause or contribute to HIE. The goal is to help doctors decide w…

This study aims to collect medical information and biological samples from 300 people with TANGO2-related disorder, a rare genetic condition. By tracking health events like metabolic and cardiac crises over time, researchers hope to better understand the disease course. The goal …

This study looks at whether giving children a sedative called dexmedetomidine (Precedex) can lower the amount of sevoflurane anesthesia needed during surgery. Researchers will test two different doses in 180 children aged 1 month to 3 years. The goal is to find the right balance …