Could a simple cream prevent painful UTIs in baby boys?

NCT ID NCT07508124

Recruiting now Prevention Sponsor: Baylor College of Medicine Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Aug 07, 2026 · Updated 2 times

Summary

This pilot study tests whether applying a steroid cream to the foreskin for four weeks can prevent recurrent urinary tract infections (UTIs) in uncircumcised male infants under 6 months who have had their first fever-related UTI. Forty infants will receive either the steroid cream or a placebo. The main goal is to see if a larger study is feasible, not yet to prove the cream works.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: betamethasone valerate 0.1% cream (a steroid cream)
What this could lead to: If this works, it could point toward a simple, non-surgical way to prevent repeat urinary tract infections in uncircumcised baby boys.
What could go wrong: This is a very small pilot study (40 infants) testing the study design, not the treatment's effectiveness. The cream may not reduce infections, and side effects from steroids on sensitive skin are possible.

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Conditions

The condition(s) this trial relates to.

urinary tract infection urinary tract infections, recurrent, susceptibility to prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

URINARY TRACT INFECTION

Contacts and locations

Locations

Seattle Children's Hospital
NOT_YET_RECRUITING

Seattle, Washington, 98105, United States
Texas Children's Hospital Main campus
RECRUITING

Houston, Texas, 77030, United States
Texas Children's Hospital West Campus
NOT_YET_RECRUITING

Katy, Texas, 77094, United States

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