Could a single chemo drug beat the standard combo for this rare cancer?

NCT ID NCT02670707

Recruiting now Disease control Sponsor: Baylor College of Medicine Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This phase 3 trial compares two chemotherapy approaches for children and young adults with Langerhans cell histiocytosis (LCH), a rare cancer that can damage tissues. One group gets the standard two-drug combo (vinblastine/prednisone), while the other gets a single drug called cytarabine. The study aims to see which treatment better prevents the disease from getting worse or coming back over one year, and also looks at genetic markers that might predict response.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Cytarabine (chemotherapy drug)
What this could lead to: If cytarabine works better than the current standard, it could become a new frontline treatment for LCH, potentially reducing relapse and improving survival.
What could go wrong: This is an early-stage comparison; cytarabine may not prove superior and could have side effects like low blood counts. The trial is still recruiting, so results are years away.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Histiocytosis, Langerhans-Cell Langerhans cell histiocytosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

LANGERHANS CELL HISTIOCYTOSIS

Contacts and locations

Locations

Children's Hospital of San Antonio
RECRUITING

San Antonio, Texas, 78207, United States
Children's Hospital of The King's Daughters
RECRUITING

Norfolk, Virginia, 23507, United States
Cook Children's Health Care System
RECRUITING

Fort Worth, Texas, 76104, United States
Dell Children's Medical Center
RECRUITING

Austin, Texas, 78723, United States
Lehigh Valley Health Network- Cedar Crest
RECRUITING

Allentown, Pennsylvania, 18103, United States
Nationwide Children's Hospital
RECRUITING

Columbus, Ohio, 43205, United States
Rady Children's Hospital - San Diego
RECRUITING

San Diego, California, 92123, United States
Stanford Children's Hospital, Lucile Packard Children's Hospital
RECRUITING

Palo Alto, California, 94304, United States
Texas Children's Hospital
RECRUITING

Houston, Texas, 77030, United States
University of Minnesota/Masonic Cancer Center
WITHDRAWN

Minneapolis, Minnesota, 55455, United States
Vannie Cook Children's Clinic
RECRUITING

McAllen, Texas, 78503, United States

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