New pacing technique could help heart failure patients live longer

NCT ID NCT05650658

Recruiting now Disease control Sponsor: Baylor College of Medicine Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests a newer heart pacing method (His or left bundle branch pacing) against the standard method (biventricular pacing) in over 2,000 adults with heart failure and a weak heart pump. The goal is to see which approach better improves quality of life, reduces hospital stays, and lowers the risk of death. Participants will continue their usual heart failure medications alongside the pacing device.

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Conditions

The condition(s) this trial relates to.

atrioventricular block bundle branch block, familial isolated complete right heart failure systolic heart failure

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

AV BLOCK HEART FAILURE HEART FAILURE WITH REDUCED EJECTION FRACTION INTRAVENTRICULAR CONDUCTION DELAY LBBB PACING-INDUCED CARDIOMYOPATHY RBBB

Contacts and locations

Locations

Allegheny-Singer Research Institute
RECRUITING

Pittsburgh, Pennsylvania, 15212, United States
Baptist Health Louisville
RECRUITING

Louisville, Kentucky, 40207, United States
Baylor College of Medicine
RECRUITING

Houston, Texas, 77030, United States
Beth Israel Deaconess Medical Center
RECRUITING

Boston, Massachusetts, 02215, United States
CIS Clinical Research Corporation
ENROLLING_BY_INVITATION

Naperville, Illinois, 60540, United States
CIUSSS de l'Estrie - CHUS
NOT_YET_RECRUITING

Saint-Jean-sur-Richelieu, Quebec, Canada
Cleveland Clinic
RECRUITING

Cleveland, Ohio, 44195, United States
Cleveland Clinic Florida
RECRUITING

Palm Beach Gardens, Florida, 33418, United States
Columbia University Medical Center/New York-Presbyterian Hospital (CUMC/NYPH)
NOT_YET_RECRUITING

New York, New York, 10032, United States
Florida Heart and Vascular, LLC dba Florida Heart Rhythm Specialist, PLLC
NOT_YET_RECRUITING

South Pasadena, Florida, 33707, United States
Geisinger Commonwealth School of Medicine
RECRUITING

Scranton, Pennsylvania, 18510, United States
HMH Hospitals Corporation
RECRUITING

Hackensack, New Jersey, 07601, United States
Hamilton Health Sciences (HHS)
RECRUITING

Hamilton, Ontario, Canada
Hartford Hospital
RECRUITING

Hartford, Connecticut, 06102, United States
Heart Rhythm Solutions
RECRUITING

Davie, Florida, 33328, United States
Icahn School of Medicine at Mount Sinai
RECRUITING

New York, New York, 10029, United States
Inova Heart and Vascular Institute
RECRUITING

Falls Church, Virginia, 22042, United States
Lehigh Valley Hospital Inc.
RECRUITING

Allentown, Pennsylvania, 18103, United States
Lovelace Medical Center
RECRUITING

Albuquerque, New Mexico, 87102, United States
MH Mission Hospital LLLP- Asheville Cardiology Associates
RECRUITING

Asheville, North Carolina, 28803, United States
Massachusetts General Hospital
RECRUITING

Boston, Massachusetts, 02114, United States
Mayo Clinic
RECRUITING

Rochester, Minnesota, 55905, United States
Mazankowski Alberta Heart Institute/University of Alberta
NOT_YET_RECRUITING

Edmonton, Alberta, Canada
Medical University of South Carolina (MUSC)
RECRUITING

Charleston, South Carolina, 29425, United States
Mercy Gilbert & Chandler Regional Medical Centers, Gilbert AZ
RECRUITING

Gilbert, Arizona, 85297, United States
Montreal Heart Institute
RECRUITING

Montreal, Quebec, Canada
Mount Sinai Medical Center of Florida, Inc.
NOT_YET_RECRUITING

Miami Beach, Florida, 33140, United States
Newark Beth Israel Medical Center
RECRUITING

Newark, New Jersey, 07112, United States
Newmarket Electrophysiology Research Group Inc. (NERG)
RECRUITING

Newmarket, Ontario, Canada
Northwestern University
RECRUITING

Evanston, Illinois, 60208, United States
Nova Scotia Health Authority
RECRUITING

Halifax, Nova Scotia, Canada
Novant Health
RECRUITING

Charlotte, North Carolina, 28204, United States
Oregon Health & Science University
RECRUITING

Portland, Oregon, 97239, United States
Penn Medicine Lancaster General
RECRUITING

Lancaster, Pennsylvania, 17603, United States
Prisma Health-Upstate
NOT_YET_RECRUITING

Greenville, South Carolina, 29605, United States
Research Institute of the McGill University Health Centre (RI-MUHC) - MUHC, Montreal General Hospital
RECRUITING

Montreal, Canada
Rush University
RECRUITING

Chicago, Illinois, 60612, United States
Sentara Healthcare
RECRUITING

Newport News, Virginia, 23606, United States
South Denver Cardiology Associates
RECRUITING

Littleton, Colorado, 80124, United States
St. Luke's University Health Network
RECRUITING

Allentown, Pennsylvania, 18015, United States
St. Mark's Hospital
RECRUITING

Salt Lake City, Utah, 84124, United States
Sunnybrook Research Institute
RECRUITING

Toronto, Ontario, Canada
Texas Health Research & Education Institute
NOT_YET_RECRUITING

Arlington, Texas, 76011, United States
The Christ Hospital
RECRUITING

Cincinnati, Ohio, 45219, United States
The MetroHealth System
RECRUITING

Cleveland, Ohio, 44109, United States
The Valley Hospital, Inc.
RECRUITING

Ridgewood, New Jersey, 07450, United States
Thomas Jefferson University Hospital
RECRUITING

Philadelphia, Pennsylvania, 19107, United States
Trustees of Indiana University
RECRUITING

Indianapolis, Indiana, 46202, United States
University of Arizona College of Medicine- Phoenix
RECRUITING

Tucson, Arizona, 85719, United States
University of Arkansas for Medical Sciences (UAMS)
RECRUITING

Little Rock, Arkansas, 72205, United States
University of British Columbia
RECRUITING

Vancouver, British Columbia, Canada
University of Calgary
RECRUITING

Calgary, Canada
University of California San Diego
RECRUITING

La Jolla, California, 92093, United States
University of Chicago
RECRUITING

Chicago, Illinois, 60637, United States
University of Colorado (Anschutz Medical Campus)
RECRUITING

Denver, Colorado, 80217, United States
University of Florida Jacksonville
NOT_YET_RECRUITING

Jacksonville, Florida, 32211, United States
University of North Carolina
RECRUITING

Chapel Hill, North Carolina, 27599, United States
University of Ottawa Heart Institute
RECRUITING

Ottawa, Ontario, Canada
University of Pennsylvania
RECRUITING

Philadelphia, Pennsylvania, 19104, United States
University of Pittsburg
RECRUITING

Pittsburgh, Pennsylvania, 15213, United States
University of South Florida
RECRUITING

Tampa, Florida, 33613, United States
University of Vermont
RECRUITING

Burlington, Vermont, 05402, United States
University of Virginia Health System
RECRUITING

Charlottesville, Virginia, 22908, United States
University of Washington
RECRUITING

Seattle, Washington, 98195, United States
Université Laval
RECRUITING

Québec, Canada
Victoria Cardiac Arrhythmia Trials (VCAT) Inc.
RECRUITING

Victoria, British Columbia, Canada
Virginia Commonwealth University
RECRUITING

Richmond, Virginia, 23284, United States
Virtua Health
RECRUITING

Marlton, New Jersey, 08053, United States
Waterloo Wellington Cardiovascular Research Institute (WWCRI) - St. Mary's General Hospital
RECRUITING

Kitchener, Canada
Weill Cornell Medicine
RECRUITING

New York, New York, 10021, United States
Yale University
RECRUITING

New Haven, Connecticut, 06511, United States

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