Could growth hormone ease gulf war illness symptoms?
NCT ID NCT05355272
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests whether growth hormone replacement therapy is safe and effective for veterans with Gulf War Illness who also have a growth hormone deficiency. Twenty veterans will receive the hormone for six months, and researchers will measure changes in belly fat, symptoms, and heart health risks. The goal is to see if a larger trial is worthwhile.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- recombinant human growth hormone (somatropin)
- What this could lead to
- If it works, this could point toward a treatment for growth hormone deficiency in veterans with Gulf War Illness, potentially reducing belly fat and improving symptoms.
- What could go wrong
- This is a small, early-phase trial with only 20 participants, so results may not apply to all veterans. Growth hormone therapy can have side effects like joint pain and fluid retention.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Phase 2
Tests whether the treatment actually works, and watches for side effects, in a larger group.
- Participants
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About 20 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Mar 2024
- Expected to finish
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Jul 2027
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 64 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: 1. veteran of the Gulf War conflict with a history of deployment to Operation Desert Storm or Desert Shield between 1990-91 2. age less than or equal to 64 years old 3. have a diagnosis of Gulf War Illness assessed by study investigators 4. have adult growth hormone deficiency diagnosed by glucagon stimulation test (cut point 3.0 mcg/L if BMI is less than or equal to 25 or 1.0 mcg/L if BMI is greater than 25) 5. 4-week stability on any psychotropic medications 6. 3-month stability on all hormone treatments 7. able and willing to provide informed consent to participant in the study and complete study protocol Exclusion Criteria: 1. history of a psychiatric disorder with substantial impact on functional status or quality of life (e.g., schizophrenia, schizoaffective disorder, bipolar, or other psychotic disorder) 2. history of neurologic disorder other than traumatic brain injury with substantial impact on the quality of life 3. other known cause for growth hormone deficiency (GHD) including history of childhood onset GHD, hypothalamic/pituitary disease, history of brain radiation, or genetic mutations known to lead to GHD 4. active suicidal ideation as determined by a score of 2 points or higher on the Columbia Suicide Severity Rating Scale 5. suicidal behavior in the past 6 months 6. contraindication to recombinant human growth hormone (rhGH) such as hypersensitivity to rhGH or any of the components of the supplied product 7. acute medical illness, active infection, cancer, or decompensated chronic medical illness (e.g., decompensated diabetes mellitus, congestive heart failure, chronic obstructive pulmonary disease) 8. evidence of substance use disorder in the past 6 months other than mild alcohol or cannabis use disorder diagnosed by clinician at time of screening. 9. urine toxicology evidence of illicit drug use (excluding cannabis) within the past 90 days prior to screening 10. BMI \> 35 or body weight \> 350 lbs 11. abnormal pituitary anatomy documented by an MRI using a Sella protocol 12. women who are pregnant or of child-bearing potential who are unable/unwilling to use one of the following barrier contraceptives: condoms, diaphragm, cervical cap, or intrauterine device 13. current use of the following: growth hormone, estrogen or estrogen-like dietary supplements, hormonal contraceptives, progestin, insulin growth factor 1 (IGF-1), or chronic glucocorticoid use in supraphysiologic doses 15\) currently enrolled in any other interventional drug trials unless prior approval is provided by the study chairs and the study sponsor
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
2 sites. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Michael E. DeBakey VA Medical Center
RECRUITINGHouston, Texas, 77030, United States
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VA Puget Sound Healthcare System
RECRUITINGSeattle, Washington, 98108, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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- Weekly shot could replace daily hormone injections for adults
- Could a common supplement ease gulf war illness symptoms?
- New weekly shot could help adults with growth hormone deficiency
- Japan study tracks Sogroya's Long-Term safety in severe hormone deficiency
- New growth hormone drug enters first human tests