Half-Matched stem cell transplants get safer with new Cell-Sorting technique

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion criteria for Stem Cell Transplant WITH Conditioning (COHORT 1) 1. Patient requiring allogeneic SCT 2. Age between birth and 70 years 3. Patient and/or responsible person able to understand and sign consent Exclusion criteria for Stem Cell Transplant WITH Conditioning (COHORT 1) 1. Active, acute GvHD \> grade II or extensive, chronic GvHD 2. Severe life, threatening infection 3. Pulmonary dysfunction (FEV1, FVC or DLCO 40% of predicted or 3 SD below normal) 4. Cardiac dysfunction (LVSF less than 25%) 5. Psychiatric disturbance 6. Lansky or Karnofsky score \< 50% 7. The presence of severe hepatic disease (direct bilirubin \>3x upper limit of normal and AST \> 5x upper limit of normal). 8. Creatinine \> 3x normal 9. Known HIV Positivity 10. Pregnancy Inclusion Criteria for CD34+ Topoff WITHOUT conditioning (COHORT 2) 1. Allogeneic SCT Recipient requiring additional cellular therapy 2. Age between birth and 70 years 3. Patient and/or responsible person able to understand and sign consent 4. At least ONE of the following must be answered YES for a patient to be eligible to receive CD34+ topoff: 1. Evidence of mixed chimerisms (less than 95% donor cells) 2. Evidence of poor bone marrow function (bone marrow cellularity less than 50% with at least one cytopenia) 3. Relapsed or persistent disease Exclusion criteria for CD34+ Topoff WITHOUT conditioning (COHORT 2) 1. Active, acute GvHD \> grade II or extensive, chronic GvHD 2. Severe life, threatening infection 3. Known HIV positivity 4. Pregnancy Inclusion Criteria for CD34+ Topoff WITH conditioning (COHORT 3) 1. Allogeneic SCT Recipient requiring additional cellular therapy 2. Age between birth and 70 years 3. Patient and/or responsible person able to understand and sign consent 4. At least ONE of the following must be answered YES for a patient to be eligible to receive CD34+ topoff: 1. Evidence of mixed chimerisms (less than 95% donor cells) 2. Evidence of poor bone marrow function (bone marrow cellularity less than 50% with at least one cytopenia) 3. Relapsed or persistent disease Exclusion criteria for CD34+ Topoff WITH Conditioning (COHORT 3) 1. Active, acute GVHD \> grade II or extensive, chronic GvHD 2. Severe life, threatening infection 3. Pulmonary disfunction (FEV1, FVC or DLCO 40% of predicted or 3 SD below normal) 4. Cardiac dysfunction (LVSF less than 25%) 5. Psychiatric disturbance 6. Lansky or Karnofsky score \< 50% 7. The presence of severe hepatic disease (direct bilirubin \> 3x upper limit of normal and AST \> 5x upper limit of normal) 8. Creatinine \> 3x normal 9. Known HIV positivity 10. Pregnancy