Supercharged immune cells take aim at tough T-Cell cancers

NCT ID NCT03081910

Recruiting now Disease control Sponsor: Baylor College of Medicine Source: ClinicalTrials.gov ↗

First seen Sep 30, 2025 · Last updated Jun 14, 2026 · Updated 31 times

Summary

This early-stage trial tests a new treatment for people with T-cell leukemia or lymphoma that has come back. Doctors take a patient's or donor's immune cells, add a special receptor (anti-CD5 with CD28) to help them recognize and attack cancer cells, then give them back. The main goal is to find a safe dose and see if the cells can shrink tumors. The study is currently recruiting, but the arm using the patient's own cells is now closed.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••
Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

Houston Methodist Hospital
RECRUITING

Houston, Texas, 77030, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••
Texas Children's Hospital
RECRUITING

Houston, Texas, 77030, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••

Conditions

Explore the condition pages connected to this study.

T-CELL ACUTE LYMPHOBLASTIC LEUKEMIA T-CELL ACUTE LYMPHOBLASTIC LEUKEMIA T-CELL ACUTE LYMPHOBLASTIC LYMPHOMA T-CELL ACUTE LYMPHOBLASTIC LYMPHOMA T-NON-HODGKIN LYMPHOMA T-NON-HODGKIN LYMPHOMA