Engineered donor cells take on lymphoma in early trial
NCT ID NCT04288726
First seen Jun 25, 2026 · Last updated Jul 15, 2026 · Updated 3 times
Summary
This early-phase study tests a new approach for patients with certain lymphomas (Hodgkin, NK/T-cell, and others) that have returned or not responded to treatment. The therapy uses immune cells from healthy donors that are specially trained in the lab to attack cancer cells carrying a protein called CD30, and also to target the Epstein-Barr virus if present. The main goals are to find the safest dose and to see if the treatment can shrink tumors.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- donor immune cells (T cells) engineered to recognize CD30 and Epstein-Barr virus
- What this could lead to
- If it works, this could offer a new treatment option for patients with lymphomas that have not responded to standard therapy.
- What could go wrong
- This is a very early phase 1 trial with only 18 participants, so it is not yet known if the treatment is safe or effective. There are risks of serious side effects, including allergic reactions and graft-versus-host disease.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Houston Methodist Hospital
RECRUITINGHouston, Texas, 77030, United States
-
Texas Children's Hospital
RECRUITINGHouston, Texas, 77030, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Can immune cells plus a checkpoint drug outsmart lymphoma?
- Can an immune booster outsmart brain lymphoma?
- A shot at safer CAR t: early brain protection for lymphoma patients?
- Can donor immune cells be engineered to fight blood cancer?
- Can a simple blood test spot lymphoma earlier?
- Can a Five-Drug combo tame a tough lymphoma without standard chemo?