New heart failure drug JK07 enters Mid-Stage trial

NCT ID NCT06369298

Ongoing Disease control Sponsor: Salubris Biotherapeutics Inc Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This Phase 2 trial tests JK07, a lab-made protein designed to help heart cells repair and pump better. About 282 adults with chronic heart failure will receive either JK07 or a placebo. The study looks at safety and whether JK07 can improve heart function in two groups: those with very weak hearts and those with moderately weak hearts.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

JK07 (a lab-made protein that targets HER3 and delivers a growth factor signal to heart cells)

What this could lead to

If it works, JK07 could offer a new way to improve heart pumping strength and manage symptoms in people with chronic heart failure.

What could go wrong

This is a mid-stage trial with 282 participants, so results are not yet proven. The drug may cause side effects or fail to show meaningful benefit over placebo.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

atrial fibrillation atrial flutter diastolic heart failure fibromatosis, gingival, 2 heart failure systolic heart failure

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HEART FAILURE WITH PRESERVED EJECTION FRACTION HEART FAILURE WITH REDUCED EJECTION FRACTION

Contacts and locations

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Locations

Site 100

Cleveland, Ohio, 44195, United States
Site 101

Portland, Oregon, 97239, United States
Site 102

Stanford, California, 94305, United States
Site 103

Houston, Texas, 77030, United States
Site 104

Covington, Louisiana, 70433, United States
Site 105

St Louis, Missouri, 63136, United States
Site 106

St Louis, Missouri, 63110, United States
Site 107

Rochester, Minnesota, 55905, United States
Site 109

Cary, North Carolina, 27518, United States
Site 110

Dallas, Texas, 75235, United States
Site 111

Phoenix, Arizona, 85016, United States
Site 112

Indianapolis, Indiana, 46250, United States
Site 113

Torrance, California, 90502, United States
Site 114

Hialeah, Florida, 33016, United States
Site 115

Dallas, Texas, 75246, United States
Site 116

Pasadena, California, 91105, United States
Site 117

Cincinnati, Ohio, 45219, United States
Site 118

Baltimore, Maryland, 21201, United States
Site 119

Boston, Massachusetts, 02114, United States
Site 121

Alexander City, Alabama, 35010, United States
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Bloomfield Hills, Michigan, 48304, United States
Site 123

Falls Church, Virginia, 22042, United States
Site 126

Norfolk, Virginia, 23507, United States
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Little Rock, Arkansas, 72205, United States
Site 128

Huntington Beach, California, 92648, United States
Site 129

Santa Maria, California, 93454, United States
Site 130

Birmingham, Alabama, 35211, United States
Site 133

Vista, California, 92081, United States
Site 135

Oklahoma City, Oklahoma, 73135, United States
Site 136

Atlanta, Georgia, 30343, United States
Site 137

Fort Wayne, Indiana, 46804, United States
Site 138

Huntsville, Alabama, 35801, United States
Site 139

Birmingham, Alabama, 35294, United States
Site 140

Charlotte, North Carolina, 28204, United States
Site 143

Boise, Idaho, 83712, United States
Site 144

Brick, New Jersey, 08724, United States
Site 145

Durham, North Carolina, 27710, United States
Site 148

Arlington, Virginia, 22205, United States
Site 149

Tomball, Texas, 77375, United States
Site 150

Farmington Hills, Michigan, 48334, United States
Site 152

Asheville, North Carolina, 28803, United States
Site 153

Valhalla, New York, 10595, United States
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Park Ridge, Illinois, 60068, United States
Site 155

York, Pennsylvania, 17403, United States
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Ponce, 00717, Puerto Rico
Site 157

Los Angeles, California, 90033, United States
Site 158

Orange, California, 92868, United States
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Naples, Florida, 34104, United States
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Chicago, Illinois, 60611, United States
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Coral Gables, Florida, 33134, United States
Site 162

Miami Lakes, Florida, 33014, United States
Site 163

Vienna, Virginia, 22182, United States
Site 200

Chicoutimi, Quebec, G7H 7K9, Canada
Site 201

Trois-Rivières, Quebec, G9A 4P3, Canada
Site 202

Winnepeg, Manitoba, R2H2A6, Canada
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Brampton, Ontario, L6Z 4N5, Canada
Site 300

Beijing, 100037, China
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Chengdu, Sichuan, 610041, China
Site 303

Nanjing, Jiangsu, 210009, China
Site 304

Chongqing, 404000, China
Site 305

Changsha, Hunan, 410005, China
Site 306

Jining, Shandong, 272100, China