Iron infusions put to the test for heart failure stamina

NCT ID NCT05816265

Terminated Disease control Sponsor: Radha Gopalan Source: ClinicalTrials.gov ↗

First seen Jul 29, 2026 · Last updated Jul 30, 2026 · Updated 1 time

Summary

This trial tests whether a single intravenous iron infusion can improve exercise capacity in people with heart failure and iron deficiency. Participants are randomly assigned to receive the infusion or no treatment, then undergo cardiopulmonary exercise testing to measure peak oxygen uptake. The study also tracks quality of life using a heart-failure questionnaire and a six-minute walk test.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: an intravenous iron infusion (ferric carboxymaltose)
What this could lead to: If it works, this could point toward a simple treatment to improve exercise tolerance and quality of life in people with heart failure and low iron.
What could go wrong: This is a very small, early-phase trial with only 6 participants, so results may not apply broadly. Iron infusions carry a small risk of allergic reactions or iron overload.

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Conditions

The condition(s) this trial relates to.

heart failure iron deficiency anemia Motor Activity systolic heart failure

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HEART FAILURE IRON-DEFICIENCY

Contacts and locations

Locations

Banner - University Medical Center, Phoenix campus

Phoenix, Arizona, 85006, United States

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