Gum stem cells could regrow teeth and bone

NCT ID NCT03570333

Completed Knowledge-focused Sponsor: University of Alabama at Birmingham Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looked at stem cells taken from two different areas of the gums (the front and back of the palate) to see which ones are better at forming bone and other dental tissues. Researchers collected gum tissue from 7 people and grew the cells in the lab to test their ability to turn into bone, cartilage, and ligament fibers. The goal is to learn how to best use these cells for future dental tissue regeneration.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: gingival mesenchymal stem cells
What this could lead to: If successful, this research could point toward new ways to regenerate gum and bone tissue for dental repairs.
What could go wrong: This is a very small, early lab study with only 7 participants. It only tests cells in a dish, not in people, so it may not lead to any treatment.

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Conditions

The condition(s) this trial relates to.

Bicuspid Aortic Valve Disease gingival recession

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

GINGIVAL RECESSION LACK OF KERATINIZED GINGIVA (DISORDER)

Contacts and locations

Locations

UAB School of Dentistry Department of Periodontology

Birmingham, Alabama, 35294-0007, United States

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