Tooth infection treatment showdown: MTA vs. standard sealers

NCT ID NCT07653997

Completed Disease control Sponsor: Istanbul Medipol University Hospital Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested two different materials used in root canal treatment for teeth with both root and gum infections. 120 adults received either a mineral-based plug (MTA) or a standard resin sealer. Researchers measured healing and inflammation markers after one year to see which approach works better.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Mineral Trioxide Aggregate (MTA) and resin-based sealer (AH Plus)
What this could lead to: If MTA proves better, it could become the preferred material for treating complex tooth infections, improving healing and saving more teeth.
What could go wrong: This is a small, completed trial with 120 participants, so results may not apply to everyone. The study only followed patients for one year, so long-term benefits are unknown.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Periapical Diseases periapical periodontitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

APICAL PERIODONTITIS ENDODONTIC-PERIODONTAL LESIONS PERIAPICAL DISEASE

Contacts and locations

Locations

Istanbul Medipol University, Faculty of Dentistry, Department of Endodontics

Istanbul, Turkey (Türkiye)

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