Root canal may lower inflammation and protect arteries, study suggests

NCT ID NCT07292363

Completed Knowledge-focused Sponsor: University of Turin, Italy Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at whether treating a chronic tooth infection (apical periodontitis) can reduce inflammation and improve the health of blood vessel walls. Researchers measured inflammatory markers and blood vessel barrier proteins in 45 healthy adults aged 25-55, both with and without tooth infections, before treatment and again 6 and 12 months after root canal therapy. The goal is to see if treating the infection can lower inflammation and help prevent blood vessel damage.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: endodontic treatment (root canal therapy)
What this could lead to: If successful, this study could show that treating a tooth infection helps reduce inflammation and protect blood vessel health.
What could go wrong: This is a small, completed observational study with only 45 participants. It does not test a new treatment and cannot prove cause and effect.

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Conditions

The condition(s) this trial relates to.

chronic apical periodontitis Inflammation periapical periodontitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

APICAL PERIODONTITIS HEALHTY

Contacts and locations

Locations

Department of Oncology - University of Turin

Turin, Italy, 10126, Italy
Endodontics, Department of Surgical Sciences - Univeristy of Turin

Turin, Italy, 10126, Italy

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