Root canal may lower inflammation and protect arteries, study suggests
NCT ID NCT07292363
First seen Jan 11, 2026 · Last updated Jun 23, 2026 · Updated 18 times
Summary
This study looked at whether treating a chronic tooth infection (apical periodontitis) can reduce inflammation and improve the health of blood vessel walls. Researchers measured inflammatory markers and blood vessel barrier proteins in 45 healthy adults aged 25-55, both with and without tooth infections, before treatment and again 6 and 12 months after root canal therapy. The goal is to see if treating the infection can lower inflammation and help prevent blood vessel damage.
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Department of Oncology - University of Turin
Turin, Italy, 10126, Italy
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Endodontics, Department of Surgical Sciences - Univeristy of Turin
Turin, Italy, 10126, Italy
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
endodontic treatment (root canal therapy)
What this could lead to
If successful, this study could show that treating a tooth infection helps reduce inflammation and protect blood vessel health.
What could go wrong
This is a small, completed observational study with only 45 participants. It does not test a new treatment and cannot prove cause and effect.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.