Periodontitis, aggressive

This phase 3 trial tests whether the drug bimekizumab can clear or nearly clear the pustules and skin lesions of palmoplantar pustulosis (PPP) on the hands and feet. About 320 adults with moderate to severe PPP will receive either bimekizumab or a placebo for 16 weeks, with an op…

This study tests whether a hyaluronic acid gel can help regrow bone lost to severe gum disease, compared to the standard enamel matrix derivative gel or no gel at all. All treatments use a minimally invasive, non-surgical technique. Sixty adults with advanced periodontitis will b…

This study tests whether using a toothpaste with sodium bicarbonate (baking soda) and fluoride can help maintain gum health in adults who have already had non-surgical gum treatment. One hundred participants will use either the special toothpaste or a placebo for six months, whil…

This study compares personalized oral hygiene advice from an AI app versus a human dentist in 148 adults with prediabetes and gum disease. The goal is to see if AI can improve gum health and blood sugar levels as well as a dentist. Participants will have their gums and blood suga…

This study is testing whether a simple online questionnaire can accurately assess a person's risk for gum disease (periodontitis or gingivitis). About 393 adults in Saudi Arabia will fill out the questionnaire and then have a dental exam to compare results. The goal is to see if …

This study compares two types of stitches (NOVOSYN quick and MONOSYN quick) used in gum surgery to see if they heal equally well. About 84 adults having gum surgery will be randomly assigned one of the two stitches. The main goal is to check early healing signs like skin regrowth…

This study examines a possible connection between gum disease and chronic neck pain. Researchers will compare neck pain intensity and daily disability among adults aged 30-55 with healthy gums, gingivitis, or periodontitis. Participants complete pain scales and questionnaires to …

This study looks at how oral hygiene habits and gum health affect quality of life in 160 adults. Participants will have a dental exam and fill out a questionnaire about how their mouth feels day-to-day. No treatment is given—the goal is simply to understand the connection between…

This observational study looks at gum tissue from people with aggressive or chronic periodontitis and healthy gums. Researchers use advanced genetic tools to map cell types and signals that make aggressive disease different. Only small tissue and blood samples are taken during pl…

This study examines how B cells, a type of immune cell, behave in the blood and gums of people with periodontitis (gum disease). Researchers want to see if certain B cell patterns are linked to more aggressive disease and how they change after surgery. The goal is to improve diag…