New rinse may ease root canal pain better than standard

NCT ID NCT07173725

Completed Symptom relief Sponsor: Bezmialem Vakif University Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study tested whether a rinse called octenidine reduces pain after root canal treatment better than the standard rinse chlorhexidine. 142 adults with a single-rooted tooth and asymptomatic apical periodontitis received one of the two rinses during their procedure. Pain was recorded at 6, 12, 24, and 48 hours after treatment. The goal was to see if octenidine leads to less early pain.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Octenidine dihydrochloride 0.1% solution
What this could lead to: If octenidine works better, it could offer a new option to reduce pain after root canal treatment.
What could go wrong: This is a small, completed trial comparing two rinses, not a new treatment. Results may not apply to all teeth or pain types.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Pain, Postoperative periapical periodontitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

APICAL PERIODONTITIS POSTOPERATIVE PAIN

Contacts and locations

Locations

Bezmialem Vakif University Dental Hospital - Department of Endodontics

Istanbul, 34093, Turkey (Türkiye)

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