Blood clot gel vs tooth protein: which fixes gum bones better?

NCT ID NCT07183631

Completed Disease control Sponsor: Semmelweis University Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study tested two treatments for deep gum bone defects caused by periodontitis: platelet-rich fibrin (PRF), made from the patient's own blood, and enamel matrix derivative (EMD), a protein gel. Twenty-six patients received one of the treatments after surgery, and their gum health was checked at 6 months and 3 years. The goal was to see which approach better improves gum attachment and reduces pocket depth.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: platelet-rich fibrin (PRF) and enamel matrix derivative (EMD)
What this could lead to: If PRF works as well as EMD, it could offer a simpler, cheaper option for repairing gum bone damage from periodontitis.
What could go wrong: This is a small, completed Phase 4 trial with only 28 participants, so results may not apply to everyone. Both treatments are already used, so no major breakthrough is expected.

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Conditions

The condition(s) this trial relates to.

Alveolar Bone Loss chronic periodontitis periodontal disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PERIODONTAL BONE LOSS PERIODONTAL DISEASE PLATELET RICH FIBRIN

Contacts and locations

Locations

Semmelweis University

Budapest, 1088, Hungary

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