Blood clot gel vs tooth protein: which fixes gum bones better?
NCT ID NCT07183631
First seen Jun 26, 2026 · Last updated Jun 26, 2026
Summary
This study tested two treatments for deep gum bone defects caused by periodontitis: platelet-rich fibrin (PRF), made from the patient's own blood, and enamel matrix derivative (EMD), a protein gel. Twenty-six patients received one of the treatments after surgery, and their gum health was checked at 6 months and 3 years. The goal was to see which approach better improves gum attachment and reduces pocket depth.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
platelet-rich fibrin (PRF) and enamel matrix derivative (EMD)
What this could lead to
If PRF works as well as EMD, it could offer a simpler, cheaper option for repairing gum bone damage from periodontitis.
What could go wrong
This is a small, completed Phase 4 trial with only 28 participants, so results may not apply to everyone. Both treatments are already used, so no major breakthrough is expected.
Disclaimer
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Semmelweis University
Budapest, 1088, Hungary