Mouth rinse showdown: can chlorhexidine beat plaque and gingivitis?

NCT ID NCT07351370

Completed Disease control Sponsor: Dental School Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested two daily-use mouth rinses containing chlorhexidine (CHX) plus either hydrogen peroxide or cetylpyridinium chloride against a placebo rinse. Over 3 months, 81 adults used the rinse twice daily alongside normal brushing. Researchers measured plaque buildup, gum inflammation, and tooth staining to see which rinse worked best.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: chlorhexidine mouth rinse with hydrogen peroxide or cetylpyridinium chloride
What this could lead to: If effective, these mouth rinses could offer a better option for controlling plaque and gum inflammation when used alongside brushing and flossing.
What could go wrong: This is a small, completed Phase 3 trial, so results are final but may not apply to everyone. Tooth staining is a known side effect of chlorhexidine.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for CHLORHEXIDINE are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

Dental Plaque gingivitis periodontal disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CHLORHEXIDINE DENTAL PLAQUE GINGIVAL AND PERIODONTAL DISEASE MOUTHWASHES RANDOMIZED CONTROLLED TRIAL

Contacts and locations

Show contact details

Locations

NKUA School of Dentistry

Athens, Attica, Greece

More trials for these conditions

Other studies related to the condition(s) this trial covers.