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Mouth rinse showdown: can chlorhexidine beat plaque and gingivitis?

NCT ID NCT07351370

Disease control Sponsor: Dental School Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested two daily-use mouth rinses containing chlorhexidine (CHX) plus either hydrogen peroxide or cetylpyridinium chloride against a placebo rinse. Over 3 months, 81 adults used the rinse twice daily alongside normal brushing. Researchers measured plaque buildup, gum inflammation, and tooth staining to see which rinse worked best.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
chlorhexidine mouth rinse with hydrogen peroxide or cetylpyridinium chloride
What this could lead to
If effective, these mouth rinses could offer a better option for controlling plaque and gum inflammation when used alongside brushing and flossing.
What could go wrong
This is a small, completed Phase 3 trial, so results are final but may not apply to everyone. Tooth staining is a known side effect of chlorhexidine.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 3

Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.

Participants

81 people

The number who actually took part.

Started

Jan 2022

Finished

Jul 2022

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adult patients (≥18 years old) * Presence of at least 24 teeth * Presence of teeth #23-13 and #43-33 * Gingival Index (GI) ≤30% (Lindhe, 1981) * No interdental clinical attachment loss (CAL) at ≥2 non-adjacent teeth or buccal/oral CAL ≥3 mm with probing pocket depth (PPD) \>3 mm at ≥2 teeth (Tonetti et al., 2019) * No known allergy to chlorhexidine (CHX), hydrogen peroxide (H₂O₂), or cetylpyridinium chloride (CPC) * No fixed or removable orthodontic appliances or removable prostheses * No use of systemic antibiotics within the 3 months prior to the study * Non-smokers or light smokers (\<5 cigarettes/day) * Non-pregnant and non-lactating women * Absence of crowns, fixed partial dentures, or class III/IV/V composite restorations covering more than one-third of the crown, and no deep dental caries extending into dentine Exclusion Criteria: * Presented with signs of hypersensitivity, severe irritation, or discomfort during the experimental period * Were not compliant with the experimental protocol

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Conditions

The condition(s) this trial relates to.

Dental Plaque gingivitis periodontal disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Chlorhexidine Dental plaque Gingival and periodontal disease Mouthwashes Randomized controlled trial

Contacts and locations

Locations

  • NKUA School of Dentistry

    Athens, Attica, Greece

More trials for these conditions

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