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Could cleaning the gums protect a transplanted heart?

NCT ID NCT07791927

Disease control Sponsor: Baskent University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 28, 2026 · Last updated Aug 28, 2026

Summary

This trial tests whether a deep dental cleaning, called non-surgical periodontal therapy, can reduce inflammation in people who have received a heart transplant. Heart transplant recipients often have low-level inflammation that may harm the new heart, and gum disease can be a hidden source of that inflammation. Researchers will measure blood markers of inflammation before and three months after the cleaning in 20 stable patients who have had a transplant at least a year ago and have gum disease. If the therapy lowers these markers, it could become a simple addition to post-transplant care.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Non-surgical periodontal therapy, including full-mouth debridement and oral hygiene instruction
What this could lead to
If it works, treating gum disease could become a simple way to reduce chronic inflammation in heart transplant recipients, potentially improving long-term heart health.
What could go wrong
This is a small, early study with only 20 participants, so results may not apply broadly. The therapy might not lower inflammation enough to matter, and any dental procedure carries a small risk of infection or discomfort.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

20 people

The number who actually took part.

Started

Apr 2016

Finished

Jun 2019

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

Children (under 18), adults (18 to 64) and older adults (65 and over)

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Clinically stable heart transplant recipient At least one year post-transplantation Diagnosed with gingivitis or periodontitis requiring non-surgical periodontal therapy (NSPT) No systemic antibiotic use within the preceding six months No periodontal treatment within the previous year Exclusion Criteria: * Systemic inflammatory or infectious conditions that could independently affect inflammatory marker levels Uncontrolled diabetes mellitus Recent active infection requiring antibiotic therapy Periodontally healthy status (no gingivitis or periodontitis)

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Conditions

The condition(s) this trial relates to.

gingivitis periodontal disorder periodontitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Gingivitis Heart transplant Periodontitis Systemic inflammation

More trials for these conditions

Other studies related to the condition(s) this trial covers.