Blood injection may boost tooth infection healing

NCT ID NCT07320898

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at whether injecting a substance made from a patient's own blood (injectable platelet-rich fibrin, or i-PRF) could help heal teeth with chronic infection at the root. Sixty adults with infected teeth received standard root canal treatment; half also got the i-PRF injection. Researchers measured two enzymes in fluid around the tooth to see if the injection changed healing activity. The goal was to understand if i-PRF might improve recovery, not to test a cure or symptom relief.

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Conditions

The condition(s) this trial relates to.

chronic apical periodontitis periapical periodontitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Kırıkkale University, Faculty of Dentistry

    Kirikkale, Kırıkkale, 71100, Turkey (Türkiye)