Gum disease breakthrough? hyaluronic acid gel may rival standard treatment
NCT ID NCT07230522
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tested whether a hyaluronic acid gel (HyaDent BG) works as well as Emdogain, a standard treatment, for repairing bone defects caused by gum disease. Both were used with a bone graft material during surgery. Seventeen adults with advanced periodontitis took part. The goal was to see if the hyaluronic acid could reduce pocket depth, improve gum attachment, and increase bone fill similarly to Emdogain.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- hyaluronic acid gel (HyaDent BG) and enamel matrix proteins (Emdogain)
- What this could lead to
- If hyaluronic acid works as well as Emdogain, it could offer a simpler, possibly cheaper option to help regrow bone lost to gum disease.
- What could go wrong
- This is a very small study (17 people) with no blinding, so results may not hold up in larger trials. Gum disease often requires ongoing care, so this is not a permanent fix.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Departement of Periodontology, Faculty of Dental Medicine, Medical University of Sofia
Sofia, Bulgaria
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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- Could Stressed-Out gum cells be behind periodontitis?