New toothpaste and mouthwash combo takes on plaque and gingivitis
NCT ID NCT06244303
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tested whether using a stannous fluoride toothpaste along with a cetylpyridinium chloride mouthwash and a manual toothbrush reduces dental plaque and gingivitis better than using regular fluoride toothpaste with a standard toothbrush. Eighty-two adults with mild gum disease and plaque used one of the two routines at home for 12 weeks. Researchers measured plaque and gum health at several checkups to compare the two approaches.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- stannous fluoride toothpaste and cetylpyridinium chloride mouthwash
- What this could lead to
- If it works, this could point toward a more effective daily oral care routine for reducing plaque and gum inflammation.
- What could go wrong
- This is a small, completed Phase 3 trial with only 82 participants, so results may not apply to everyone. The improvement over regular toothpaste may be modest.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Mesa Dental Centre
Costa Mesa, California, 92627, United States
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Other studies related to the condition(s) this trial covers.
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