Could a cold rinse and diabetes drug soothe root canal pain?
NCT ID NCT07437612
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 2 times
Summary
This study tested whether rinsing the tooth with cold saline (cryotherapy) or placing metformin (a diabetes drug) inside the tooth can reduce pain after root canal treatment. 80 adults with infected lower premolars were randomly assigned to receive one of four treatments. Pain was tracked for a week using a standard scale. The goal is to find better ways to manage post-treatment discomfort.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
metformin and calcium hydroxide (intracanal medicaments) and cold saline (cryotherapy)
What this could lead to
If effective, this approach could offer a simple, low-cost way to reduce pain after root canal treatment.
What could go wrong
This is a small, early-phase trial (80 people) testing pain relief, not a cure. Results may not apply to all teeth or patients, and the effect may be modest.
Disclaimer
Read more
Show less
This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for PERIAPICAL PERIODONTITIS, CHRONIC NONSUPPURATIVE are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Show contact details
Enter your email to view the contact information for this study.
By submitting, you agree to our Terms of use
Locations
-
Saglik Bilimleri University
Istanbul, Turkey (Türkiye)