Could a cold rinse and diabetes drug soothe root canal pain?
NCT ID NCT07437612
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 2 times
Summary
This study tested whether rinsing the tooth with cold saline (cryotherapy) or placing metformin (a diabetes drug) inside the tooth can reduce pain after root canal treatment. 80 adults with infected lower premolars were randomly assigned to receive one of four treatments. Pain was tracked for a week using a standard scale. The goal is to find better ways to manage post-treatment discomfort.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- metformin and calcium hydroxide (intracanal medicaments) and cold saline (cryotherapy)
- What this could lead to
- If effective, this approach could offer a simple, low-cost way to reduce pain after root canal treatment.
- What could go wrong
- This is a small, early-phase trial (80 people) testing pain relief, not a cure. Results may not apply to all teeth or patients, and the effect may be modest.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Saglik Bilimleri University
Istanbul, Turkey (Türkiye)