Smoking may slow gum healing after deep cleaning, study finds

NCT ID NCT07339670

Completed Knowledge-focused Sponsor: Al-Azhar University Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looked at how smoking affects gum healing after non-surgical treatment for stage II gum disease. Researchers measured two proteins (PLAP-1 and Sclerostin) in the gum fluid of 36 patients—both smokers and non-smokers—before and after deep cleaning. The goal was to see if smoking changes the body's healing response at a molecular level.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Non-surgical periodontal treatment (scaling, root planing, and Listerine mouthwash)
What this could lead to: If successful, this study could reveal how smoking interferes with gum healing, potentially leading to better treatment approaches for smokers with gum disease.
What could go wrong: This is a small, completed observational study with only 36 participants. It measures protein levels rather than long-term health outcomes, so results may not directly change treatment.

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Conditions

The condition(s) this trial relates to.

Cigarette Smoking periodontitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PERIODONTITIS STAGE II SMOKING ( CIGARETTE)

Contacts and locations

Locations

Faculty of Dental Medicine for Girls, Al-Azhar University

Cairo, Nasr City, 4450113, Egypt

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