Gum fluid proteins may reveal hidden clues about periodontitis

NCT ID NCT06727929

Completed Knowledge-focused Sponsor: Cumhuriyet University Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study measured two proteins, Dkk-1 and sFRP5, in the gum fluid of 99 people with healthy gums, gingivitis, or periodontitis. Researchers collected samples before and after non-surgical periodontal treatment (deep cleaning) to see if these proteins change with treatment. The goal was to explore whether these proteins could serve as markers for gum disease activity.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: non-surgical periodontal treatment (scaling and root planing)
What this could lead to: If successful, this could point toward a new way to diagnose or monitor gum disease using protein levels in gum fluid.
What could go wrong: This is a small, completed study that only measured protein levels; it does not test a new treatment. The results may not apply to broader populations or lead to a diagnostic test.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Alveolar Bone Loss gingivitis periodontal disorder periodontitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ALVEOLAR BONE LOSS PERIODONTAL DISEASES PERIODONTAL INFLAMMATION

Contacts and locations

Locations

Sivas Cumhuriyet University

Sivas, Turkey (Türkiye)

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