Periodontal disorder

This study investigates how bacteria that cause tooth decay and gum disease spread among family members. Researchers will treat either the child alone, the child and parents, or all family members with professional dental cleaning. They will track bacterial transmission using DNA…

This study looks at whether a special gel, called Sterify Gel, can improve the results of standard non-surgical gum disease treatment. Researchers will review records from 20 adults with moderate to severe periodontitis who received deep cleaning plus the gel. The main goal is to…

This study tests whether adding a daily synbiotic supplement (probiotics plus prebiotic) to standard non-surgical gum treatment improves gum health in smokers with advanced periodontitis. 92 smokers and non-smokers will be split into four groups, receiving either the supplement o…

This study tests whether a hyaluronic acid mouthwash is more acceptable to children than a standard chlorhexidine mouthwash, while still controlling plaque-induced gingivitis. Thirty-two children aged 8 to 12 with signs of gingivitis will use one of the two mouthwashes. Researche…

This study tests whether a deep dental cleaning (subgingival instrumentation) can slow the progression of chronic kidney disease in 40 adults with diabetes and stage IV-V kidney disease. The cleaning aims to reduce inflammation that may worsen kidney function. Researchers will me…

This study looks at whether mobile health reminders can help people with gum disease keep their teeth cleaner after standard treatment. The trial will include 76 adults with gum disease affecting the roots of their back teeth. Participants will receive text or app reminders to im…

This study tests a gel made from doxycycline and atorvastatin in tiny chitosan particles, placed directly into gum pockets after standard deep cleaning. The goal is to reduce gum inflammation, pocket depth, and bone loss in 80 adults with moderate to severe chronic periodontitis.…

This study tests whether adding hyaluronic acid gel to standard deep cleaning (scaling and root planing) improves gum healing in people with both diabetes and advanced gum disease. Twenty-three participants will receive the standard cleaning on all teeth, and then two gum pockets…

This study tests whether adding a light-activated dye (photodynamic therapy) to standard deep cleaning improves gum disease more than cleaning alone. Thirty adults with periodontitis will have one side of their mouth treated with cleaning plus the dye/laser, and the other side wi…

This study tests a surgical procedure to cover exposed tooth roots on the tongue side of lower teeth. Twenty adults with gum recession will receive the surgery and be followed for up to 24 months. The main goal is to see how much root coverage is achieved at 6 months, along with …

This study tests whether adding hyaluronic acid gel to standard deep-cleaning treatment improves gum healing in smokers with advanced periodontitis. Twenty-three smokers will receive the standard cleaning, then some gum pockets will also get the gel. Researchers will measure gum …

This study looks at whether adding hyaluronic acid to temporary dental crowns (made by 3D printing or milling) can improve gum health and surface smoothness. Sixty adults with moderate gum disease will receive one of the two crown types, and their gum attachment, bleeding, and pl…

This study tests whether a special collagen matrix can replace tissue taken from the roof of the mouth to fix receding gums. Forty adults with at least two areas of gum recession will receive either the collagen matrix or a standard palate graft. The main goal is to see how much …

This study tests whether a special irrigation solution called nanochitosan can help regenerate damaged tissue in infected teeth. Sixty adults with dead teeth and chronic infection will receive one of three irrigation methods during a single dental visit. Researchers will check fo…

This study tests a new gel that slowly releases medicine to treat advanced gum disease (periodontitis). The gel is placed directly into deep gum pockets to fight infection, reduce swelling, and help bone grow back. Researchers will study 80 people with severe gum disease to see i…

This study tests an injectable gel containing a bone-growth protein (BMP-2) to help regrow bone damaged by severe gum disease. The gel is designed to fight bacteria, reduce inflammation, and promote bone repair. Researchers will enroll 80 people with advanced periodontitis and bo…

This study tests an experimental drug called LP-005, given as an injection into the gums, for people with moderate-to-severe gum disease (periodontitis). About 100 adults aged 18-70 will receive either the drug or a placebo to see if it reduces gum inflammation, bleeding, and bon…

This early study will test whether using a miswak chewing stick (from the Salvadora persica plant) can reduce gum inflammation better than a regular toothbrush in people with moderate gum disease (periodontitis). Researchers will measure inflammatory markers in gum fluid from 24 …

This study tests a new gel made from peptides (protein fragments) to see if it can help regrow bone and tissue damaged by gum disease. Forty adults with advanced periodontitis will receive either the new peptide gel or a standard hyaluronic acid gel during surgery. Researchers wi…

This study tests whether a cream made from phenytoin, a seizure drug known to cause gum overgrowth, can help receding gums grow back. Thirty adults who want to avoid surgery will apply either the phenytoin cream or a placebo paste. Researchers will measure changes in gum attachme…

This study compares two treatments for repairing bone damage from advanced gum disease. About 40 adults with deep gum pockets will receive either a combination of hyaluronic acid and polynucleotides (Regenfast) or enamel matrix proteins (Emdogain), both with a bone graft material…

This study compares a new, simpler treatment called CTZ paste against the standard root canal procedure for infected baby teeth in emergency settings. The CTZ paste is placed directly into the tooth without drilling or cleaning the root canals, aiming to kill bacteria and save th…

This pilot study tests whether a gel made from a special form of hyaluronan (HA35) can help people with mild gum recession and chronic gum inflammation. Thirty adults will apply the gel to their gums and teeth twice a day for 42 days. Researchers will measure changes in gum reces…

This study tests a new silk-reinforced collagen membrane designed to help regrow bone in the jaw for people with advanced gum disease (periodontitis). The membrane is placed during a dental procedure to guide bone regeneration. Researchers will measure bone fill and density using…

This study tests whether stem cells taken from donated teeth can be safely injected into the gums to treat periodontitis, a serious gum infection that damages tissue and bone. The goal is to help regrow lost gum and bone without the need for traditional surgery. The trial will en…

This study looks at how well 3D printed bone grafts work for supporting dental implants in people with gum disease or bone loss. Researchers will check if the implants stay stable and how much the graft shrinks over 1 to 6 years. About 100 healthy adults who already received this…

This study tests whether a special low-calorie diet that mimics fasting can improve the results of standard gum disease treatment in obese adults with severe periodontitis. The diet is given in three 5-day cycles around the treatment. Researchers will measure inflammation and gum…

Gum recession exposes tooth roots, causing sensitivity and cosmetic concerns. Standard surgery (CAF + SCTG) covers the root, but healing can be slow. This trial tests whether adding a hyaluronic acid gel (hyaDENT BG®) to the surgery improves root coverage and recovery. Thirty-fou…

This study tests whether adding cross-linked hyaluronic acid through microneedling after gum surgery can improve gum thickness and cover exposed tooth roots better than microneedling alone. It involves 22 adults with a single gum recession and thin gums. Participants will receive…

This study tests whether using a laser along with ultrasonic cleaning works as well as the standard manual scraping plus ultrasonic cleaning for treating advanced gum disease. About 174 adults with severe periodontitis will receive one of the two treatments on different sides of …

This Phase 3 trial will test whether a toothpaste containing chitosan, a natural substance, can reduce plaque, gingivitis, and gum bleeding better than a standard fluoride toothpaste. About 90 adults aged 18-70 with good general health will brush with either the chitosan toothpas…

This small study tests a dental implant technique that leaves a piece of the natural tooth root (socket shield) and uses a mix of growth factors and bone graft material to support the implant. Seven adults needing a front tooth implant will be followed for 6 months to check bone …

This study tests a dental implant procedure for people with thin jawbone. Surgeons will place the implant and use the patient's own bone chips and special growth factor membranes to rebuild the bone around it. The study will check bone density and gum thickness before, right afte…

This study tests a new way to place dental implants by combining a technique called socket shield (which saves a piece of the tooth root) with concentrated growth factors made from the patient's own blood. The goal is to see if this helps preserve bone and improve implant stabili…

This study tests whether a new cleaning technology (GentleWave) is better than standard methods for disinfecting root canals in molars that still have infection after initial treatment. About 60 adults with persistent infection will be randomly assigned to receive either the new …

This study compares a new cleaning solution made from ferumoxytol nanozymes to the standard treatment for root canal infections. About 72 adults with infected teeth will receive either the new solution or the usual one during their root canal procedure. Researchers will measure h…

This study looks at two different approaches to help pregnant people with gum disease get better dental care. Participants will receive free dental check-ups, cleanings, and supplies. The goal is to see which method reduces gum inflammation and improves oral health habits, and wh…

This study tests a new program that teaches pregnant women in Bangladesh how to care for their teeth and gums during routine prenatal visits. Over 95% of pregnant women in Bangladesh have gum disease, but oral health is not part of standard pregnancy care. The study will compare …

This study tests whether a probiotic lozenge containing a special strain of Streptococcus salivarius (SALI-10) can reduce gum inflammation and bad breath. Sixty adults with gingivitis will take the lozenge or a placebo twice daily for four weeks. The goal is to see if the probiot…

This study compares two materials used to fill root canals during retreatment of infected teeth: standard gutta-percha and a newer material called MTA. About 58 adults with small infections around the tooth root will be treated and followed for one year. Researchers will check he…

This trial tests whether adding a sodium hypochlorite/amino acid gel, with or without cross-linked hyaluronic acid, to standard non-surgical gum treatment helps adults with periodontitis. 78 participants will receive one of three treatments and be checked after three months. The …

This study tests whether a toothpaste and powder made from tinder fungus can improve gum health in people with advanced periodontitis. About 70 adults will use either the fungus product or a regular toothpaste alongside standard deep-cleaning treatment for 30 days. The main goal …

This study compares two medicines placed inside a tooth after root canal treatment to see which one helps heal infections around the tooth root faster. About 62 adults with infected single-rooted teeth will receive either triple antibiotic paste or calcium hydroxide. The research…

This study tests two different gum dressings—Ora-Aid and Coe-Pak—placed after a deep cleaning (scaling and root planing) in 25 adults with Stage 3 gum disease. Researchers will measure pocket depth, gum inflammation, plaque, and bacteria over 3 months to see which dressing helps …

This study tests whether a donor tooth-derived bone graft works as well as a patient's own tooth graft for preserving jawbone after impacted wisdom tooth extraction. Forty adults with similar impacted wisdom teeth on both sides of the jaw will receive one graft type per side. Res…

This study is testing a mouth rinse made from stingless bee honey as a gentler alternative to standard chemical mouthwashes for gingivitis (gum inflammation). Researchers will develop the rinse, check its safety and germ-fighting power in the lab, then test it in 20 volunteers to…

This study will test if a toothpaste with stannous fluoride can reduce bacteria on teeth, tongue, cheeks, and gums better than a regular toothpaste. About 100 adults with plaque and gingivitis will brush with one of the two toothpastes. The goal is to see which one controls bacte…

This study tests whether using a donor bone graft (allograft) works as well as using your own bone (autograft) to repair defects where a tooth infection has damaged the surrounding bone. Fifty adults with these defects will receive one of the two grafts along with a collagen memb…

This study tests whether a new mouthwash called Amphion can improve gum health when used after standard deep cleaning for periodontitis. Sixty adults with gum disease will receive either Amphion or a placebo mouthwash to use at home twice daily. The goal is to see if the mouthwas…

This study compares toothpaste tablets to a standard toothpaste (Colgate Cavity Protection) for cleaning teeth and gums. Fifty adults will use one of the two products for six weeks. Researchers will measure plaque, gum inflammation, and cavities before and after the trial to see …

This study tests whether a mouthwash made from moringa leaves can reduce dental plaque, bacteria, and early cavities as well as the standard chlorhexidine rinse. Researchers will enroll 90 adults with mild gum inflammation and moderate-to-high cavity risk. Participants will use e…

This study looks at whether adding other medicines to a standard root canal disinfectant (calcium hydroxide) can kill more bacteria in infected teeth. The trial will involve 45 adults with a tooth infection called apical periodontitis who need a repeat root canal. Researchers wil…

This study tests whether using platelet-rich fibrin (PRF) – a concentrate made from a patient's own blood – can reduce pain and improve healing after endodontic microsurgery (root-end surgery). Twenty adults with failed root canals and persistent infection in front teeth or premo…

This study tests if garlic gel can replace the usual medicine placed inside teeth during root canals. About 96 people with infected permanent teeth will get either garlic gel or calcium hydroxide. Researchers will check pain, swelling, and X-ray healing to see if garlic works as …

This 6-week study tests whether an AI-based toothbrush (Xiaomi T501) with pressure sensing and coaching removes more plaque and reduces gum bleeding than a standard electric or manual toothbrush. Thirty-three adults with plaque-induced gingivitis will be randomly assigned to one …

This study compares two surgical techniques to treat single gum recession defects, where the gum has pulled away from the tooth. One method uses a tunnel without cuts, the other adds a small cut. The goal is to see which covers the exposed root better and is less invasive. The tr…

This study tests whether a gel made from the diabetes drug metformin can improve gum healing better than a standard antimicrobial gel (chlorhexidine) when used alongside deep cleaning. Sixty adults with moderate gum disease will be split into three groups: cleaning alone, cleanin…

This study tests whether adding a special anti-inflammatory mouthwash to a deep-cleaning procedure helps heal advanced gum disease better than the cleaning alone. About 20 adults with severe gum disease will be randomly assigned to use either the active mouthwash or a placebo for…

This study tests whether a gel made from a patient's own blood (platelet-rich fibrin) can help regenerate the inner part of infected or dead teeth in adults. 57 participants will receive either the gel or a standard blood-clot treatment. The goal is to see if the gel reduces infe…

This study compares three oral hygiene routines in 90 adults aged 60+ who have gum disease and mild cognitive impairment. One group uses a special light device (Lumoral) plus a manual toothbrush, another uses a powered toothbrush (Oral-B iO), and a control group uses a manual too…

This study tests whether a less invasive dental procedure called full pulpotomy can heal infected molars as well as root canals. Researchers will treat 128 adults with deep cavities and compare healing in teeth with and without infection at the root tip. If successful, it may off…

This study tests whether sending SMS reminders and advice to people with type 2 diabetes and gum disease can improve their blood sugar control over two years. 516 adults who recently completed gum disease treatment will be split into two groups: one gets standard follow-up, the o…

This study tests whether breath samples collected in special bags remain stable for up to 7 days, which could allow people with bad breath (halitosis) to provide samples from home instead of traveling to a clinic. Researchers will compare gas levels measured right away and after …

This study tests an artificial intelligence system called PerioAI V2.0 that creates a detailed 3D map of gum disease from dental scans. Researchers will enroll 80 adults with moderate-to-severe periodontitis who need gum surgery. The AI's map will be compared to what surgeons see…

This study aims to validate an Italian version of a widely used questionnaire for screening periodontitis (gum disease). Researchers will also develop an enhanced version with additional questions and test how accurately it identifies people with the condition. About 495 adults a…

This study will check if a simple questionnaire can accurately identify gum disease in adults. About 291 participants in Saudi Arabia will fill out the questionnaire and then have a standard dental exam. The goal is to see how well the questionnaire matches the exam results, whic…

This study is developing a new, non-invasive saliva test that uses artificial intelligence to detect gum disease (periodontitis) early. Researchers will collect saliva from 200 adults—some with gum disease and some healthy—and analyze it with a special sensor. The goal is to see …

This study will enroll 2,000 adults to see if non-invasive methods like smartphone photos, dental X-rays, and questionnaires can accurately detect gum disease compared to a standard clinical exam. Researchers will use artificial intelligence to analyze the images and combine data…

This study tests whether a 3D intraoral scanner can accurately measure dental plaque compared to the traditional method of applying a dye and visually scoring. Twenty adults with at least 20 natural teeth and visible plaque will be scanned before and after plaque disclosure and a…

This study tests whether a simple, low-cost oral health program for pregnant women in rural Nepal can reduce the number of babies born too early, too small, or underweight. About 2,280 women will either receive daily antiseptic mouthwash and intensive oral hygiene education, or j…

This study tests whether a new medicine called Fexuprazan (Fexuclue) can prevent stomach ulcers caused by NSAID painkillers like ibuprofen. About 360 adults with joint or muscle pain who need daily NSAIDs will take either Fexuprazan or an older drug (Lansoprazole) for 24 weeks. T…

This pilot study will test whether a dental gel called theranovis can improve gum health in people with gingivitis (mild gum disease). Twenty adults with gingivitis will use either the gel or a placebo twice daily for a period. Researchers will measure changes in gum bleeding and…

This study tests whether motivational interviewing, a patient-centered counseling approach, can improve outcomes of standard gum disease treatment (subgingival instrumentation) in 66 adults aged 30-50 with periodontitis. Participants will receive either motivational interviewing …

This study tests whether a special behavioral program can help people with gum disease who lack confidence in their oral hygiene. 78 adults with stage I-III periodontitis will get standard gum treatment plus either the behavioral program or regular instructions. Researchers will …

This study tests a smoking cessation program delivered via telemedicine and wearable devices. About 102 adult smokers will either get the program with remote monitoring or standard in-person support. The goal is to see if the tech-based approach helps more people quit and stay sm…

This study will compare two types of tooth separators—elastomeric and nickel-titanium—used before placing orthodontic bands for braces. Thirty patients with crowded teeth will have one separator type on each side of their mouth. Researchers will measure how well they create space…

This study tests whether a newer bioceramic filling material reduces pain after root canal treatment better than the standard calcium hydroxide filling. Twenty-eight adults with painful lower molar infections will receive one of the two fillings during their root canal. Pain leve…

This study tests whether a gel made from hyaluronan (HA35) can safely reduce gum pain and swelling after dental procedures. About 30 adults will chew on gel-soaked cotton balls for 30 minutes. Researchers will measure pain and swelling changes at 1, 30, and 60 minutes after appli…

This study tests whether a special mouthwash can reduce gum inflammation (gingivitis) in adults. Thirty healthy volunteers with moderate gum redness and swelling will rinse daily for 4 weeks. Dentists will check their gums at the start and end to see if the product helps ease sym…

This study compares two ways of using an anti-inflammatory drug (ketorolac) during root canal treatment: one at room temperature and one chilled. The goal is to see if the cold version reduces pain better after the procedure. Sixty adults with tooth infections will be enrolled, a…

This study compares two ways of teaching oral hygiene to adults with braces who have gum inflammation (gingivitis). One group gets personalized training called iTOP, while the other gets standard video and model instruction. Researchers will measure plaque and gum health after th…

This early-phase trial will test four orthobiologic treatments—PRP, bone marrow concentrate, hyaluronic acid, and nanofat—in 300 adults with various muscle, joint, tendon, or bone conditions. The goal is to see if these natural substances can reduce pain and improve joint functio…

This study compares a homemade herbal mouthwash to chlorhexidine, the standard mouthwash for gingivitis. Gingivitis is a common gum disease caused by plaque buildup. The herbal option may have fewer side effects. The trial will include 12 adults with plaque-induced gingivitis and…

This study looks at whether a mobile app can help people with common pains (neck, shoulder, back, or knee) do their prescribed home exercises more regularly. About 30 adults will be split into two groups: one using the app and one doing traditional exercises. The goal is to see i…

This study compares two single-dose pain relievers—piroxicam and prednisolone—given before a root canal to see which one reduces pain better afterward. Sixty adults with an inflamed tooth nerve and infection will take one of the drugs right before treatment. The goal is to find a…

This study will test if a technique called 'apical patency'—gently passing a small file just past the root tip during cleaning—can reduce pain after a root canal. 48 adults with a dead nerve and infection in a back molar will be randomly assigned to receive either this technique …

This study tests whether a water flosser can improve oral health in adults with plaque-induced gingivitis. Sixty-four healthy adults will use the device twice daily after brushing. Researchers will measure changes in plaque and gum inflammation over time.

This study tests whether applying injectable platelet-rich fibrin (I-PRF) to the wound after gum surgery (gingivectomy or gingivoplasty) can improve healing. Twenty adults with chronic inflammatory gum overgrowth will be split into two groups: one gets standard surgery alone, the…

This study looks at whether checking gum health 4 weeks after non-surgical treatment is better than waiting 8-10 weeks. Researchers will compare healing and pocket depth in 24 adults with advanced gum disease. The goal is to find the best time for follow-up to improve care.

This study will measure how well people with gum disease can chew. One hundred adults with periodontitis will chew a special gum for 20 cycles to test their chewing performance. Researchers will also check the severity of their gum disease to see if there is a link. This is an ob…

This study looks at whether treating gum disease (periodontitis) can improve how well people chew and their overall oral quality of life. Researchers will ask 44 adults with gum disease to fill out questionnaires, do a chewing test with colored gum, and provide saliva samples. Th…

This study looks at how mental health, especially stress, affects gum disease in people who grind their teeth. About 110 adults aged 30-50 with both teeth grinding and gum disease will answer mental health questions and get a dental check-up. The goal is to see if poor mental hea…

This study aims to translate and adapt a widely used questionnaire for musculoskeletal problems into Urdu. Researchers will enroll 110 Urdu-speaking adults, including patients with muscle or joint issues and healthy volunteers. The goal is to create a validated tool to measure sy…

This study follows 70 adults aged 20-60 who need root canal treatment on a premolar or molar. Researchers measure how hard they can bite and how force spreads across teeth before treatment, after root canal, after a crown, and up to 4 years later. They also ask about chewing comf…

This study looks at how stress levels, sleep quality, and teeth grinding (bruxism) together affect gum disease in adults aged 30-45. Researchers will compare two groups of people with gum disease: those who grind their teeth and those who do not. The goal is to understand how the…

This study looks at whether psychological resilience — the ability to bounce back from stress — can reduce the harmful effects of stress on gums in people who grind their teeth (bruxers). Researchers will measure stress and resilience using questionnaires and check gum health in …

This study looks at how people with gum disease (periodontitis) value their dental health and how their oral health beliefs relate to the severity of their condition. Researchers will ask 112 adults aged 30-50 to complete questionnaires and a clinical exam in one visit. The goal …

This study looks at how obesity changes the way genes work in people with gum disease. Researchers will compare obese and non-obese adults before and after a deep cleaning treatment. They aim to understand why obese individuals may have worse gum inflammation and how it might be …

This study looks at how gum inflammation and the bacteria in your mouth interact with your body's immune system. Twenty healthy adults will use a special toothpaste and then stop brushing for a period to see how inflammation and bacteria change. The goal is to better understand t…

This study looks at how the width of healthy gum tissue affects the success of covering exposed tooth roots in 30 adults with gum recession. Participants will receive a minimally invasive gum graft surgery. The goal is to see if wider gum tissue leads to better root coverage and …

This study looks at whether people with oral lichen planus (a chronic mouth condition) have more gum disease than those without it. Researchers will compare 88 patients with oral lichen planus to 88 healthy people, all getting standard dental exams. The goal is to understand shar…

This study looks at how patients feel when reading their own medical notes. Some will read the original doctor's note, others will read a simpler version written by artificial intelligence. Researchers want to see if the AI summary changes how much patients trust their doctor or …

This study will check if people with Lynch syndrome, a genetic condition that raises cancer risk, have more gum disease than the general population. Researchers will look at dental records from 25 adults with Lynch syndrome. The goal is to see if gum disease is a hidden health is…

This study will measure certain proteins and antioxidants in the fluid from gum pockets in 21 adults with gum disease. Researchers will take samples before and after a deep cleaning procedure (scaling and root planing) to see how these markers change during healing over 3 months.…

This study looks at whether a deep dental cleaning (called non-surgical periodontal therapy) can change levels of a substance called asprosin in the blood of people who have both stable angina and gum disease. Asprosin is a protein that may play a role in heart health and inflamm…

This study looks at how a disrupted body clock (like in night-shift workers) affects gum inflammation. Researchers will measure clock proteins and immune markers in the gum fluid of 116 people with and without gum disease. The goal is to understand the link between sleep-wake cyc…

This study looks at how well the mouth heals after gum surgery in people with diabetes compared to those without. Researchers will track healing, measure gum recession, and check factors like bacteria and inflammation. The goal is to understand what affects recovery in diabetic p…

This study follows 400 obese adults in Norway to see how weight loss from lifestyle changes, medication, or surgery affects their oral health. Researchers will measure gum disease, cavities, and tooth erosion before and after weight loss. The goal is to understand the link betwee…

This study gathers mouth pictures from 150 adults with different gum conditions to teach an AI system how to spot gum disease. Participants simply have their teeth and gums photographed with a special probe. No treatment or medication is involved—just data collection to improve f…

This study looks at how the mouth heals after gum surgery in people with and without diabetes. Researchers will measure wound size and track healing over 12 weeks. They will also check bacteria and inflammation levels to see what affects recovery. The goal is to learn why healing…

This study looks at how gum surgery changes inflammation markers in the blood. Researchers will take blood samples from 30 adults before, during, and after dental procedures. The goal is to see if surgical stress causes a different inflammatory response compared to non-surgical c…

This study will check if certain gene variations (MMP-2 and MMP-3) are linked to how well the bone around a tooth heals after root canal treatment. Fifty adults with chronic tooth infections will get standard root canal therapy and be followed for 12 months. Researchers will comp…

This study aims to see if the amount of plaque on teeth can predict how well non-surgical gum treatment works. Researchers will follow 100 adults with gum disease for 12 months after treatment, measuring pocket depth and other gum health signs. The goal is to understand if a simp…

This study will examine 108 adults aged 30-65 to see if a gene called Klotho, certain mouth bacteria, and viruses are linked to gum disease and acute coronary syndrome (a type of heart attack). Researchers will measure gum health and collect samples to look for these markers. The…

This observational study looks at how gum disease (periodontitis) and chronic kidney disease may be related. Researchers will examine mouth and gut bacteria in 80 adults aged 18 to 75 to see if these microbes play a role in the link between the two conditions. The goal is to bett…

This study looks at three different ways to clean infected root canals in 66 men aged 18-35. The goal is to see which method best reduces signs of inflammation and infection. Researchers will measure certain proteins in the fluid around the tooth root before and after treatment.

This study looks at the teeth, mouth, and face health of 25 people with Mowat-Wilson syndrome, a rare genetic condition. Researchers will check for cavities, gum disease, and facial features, and ask about quality of life. No treatment is given—the goal is to gather information t…

This observational study looks at whether eating a diet that causes inflammation can make gum disease worse in people with metabolic syndrome. About 100 adults with metabolic syndrome will have their gum health checked and their diet analyzed using a special inflammation score. T…

This observational study looks at whether eating lots of ultra-processed foods (like chips, soda, and packaged snacks) is linked to cavities and gum disease. Researchers will track the diets and oral health of 200 adults aged 18 to 65. No treatments or changes are given—just care…

This observational study looks at whether a diet that promotes inflammation can make gum disease worse in people with chronic kidney disease. Researchers will assess the diets and gum health of 100 adults with kidney disease. The goal is to understand if eating more inflammatory …

This study looks at how much final-year dentistry and psychology students know about gum disease (periodontitis) and whether that knowledge is linked to their own gum health. About 60 students will fill out a questionnaire and get a dental check-up. The goal is to see if more kno…

This study will check the gum health of 100 people—half with multiple sclerosis (MS) and half without—by measuring gum pockets, plaque, and inflammation. Researchers will also test saliva for certain bacteria and viruses to see if they are linked to MS. The goal is to better unde…

This study will test several over-the-counter mouthwashes to see how they affect the balance of bacteria in the mouth and whether they influence heart health. Researchers will recruit 200 adults with or without gum disease from dental clinics and a university campus. The goal is …

This study will follow 75 adults who need root canal treatment or retreatment at a hospital dental clinic in Rome. Researchers will check how well the teeth heal using X-rays and symptom reports over up to 5 years. The goal is to understand success rates and how factors like over…

This study looks at whether standard gum treatment can improve heart health in people with stable angina. Researchers will measure certain blood markers before and after a routine dental cleaning. The study involves 60 adults, some with heart disease and some without. It aims to …

This study looks at how two types of dental cement used to attach stainless steel crowns affect gum health in 45 children aged 6-10. Researchers measured gum inflammation and certain immune markers before and one week after placing the crowns. The goal is to see if one cement cau…

This study looks at whether certain substances in spit and fluid around dental implants can help detect a gum disease called peri-implantitis early. Researchers will compare 80 people with healthy gums, regular gum disease, or implant-related gum disease. The goal is to find bett…

This observational study will follow 94 transgender individuals for 12 months to see how gender-affirming hormone therapy affects their mood, stress, and heart health. Researchers will measure inflammation, blood vessel function, and other markers to understand potential cardiova…

This study will test three common techniques for removing a tiny amount of enamel between teeth to make room for clear aligners. Seventy-five adults will be randomly assigned to manual strips, motor-driven strips, or abrasive discs. The main goal is to see which method most close…

This study looks at how metabolic syndrome (a cluster of conditions like high blood pressure and blood sugar) might make gum disease worse. Researchers will measure gum inflammation in 100 adults and compare it to their metabolic health. The goal is to see if a simple gum measure…

This study tests a decision support system called SmaRTWork to help people on sick leave due to muscle or back pain return to work. About 298 adults in Norway will either use the system or receive usual care. The main goal is to see if the tool helps them return to work sustainab…

This study will test three ways to clean clear aligners: brushing with fluoride toothpaste, using chlorhexidine mouthwash, or using an oxygen-based cleanser. Twenty-one adults will try each method for one month to see how it affects bacteria and gum health. The goal is to find wh…

This study explores whether a health app and follow-up digital meetings can motivate teenagers to improve their oral hygiene. Researchers will interview 25 adolescents aged 16-17 who have gum disease (gingivitis) to see if the app helps them build better brushing habits. The goal…

This study looks at how well root canal treatments work when done in general dental clinics, rather than specialist offices. Researchers will check about 1500 patients who had root canals in 2023 to see if infections remain after treatment. The goal is to understand why results m…

This study aims to find out if tiny plastic particles, called microplastics, are present in the deep gum pockets of people with severe gum disease (periodontitis). Researchers will collect plaque from 25 adults with advanced gum disease who have not yet started treatment. The goa…

This study looks at whether teeth that bear more chewing force are more likely to have severe gum disease. Researchers will measure bite patterns in 50 adults with natural teeth or fixed dental work. The goal is to understand the link between chewing loads and gum health, which c…

This pilot study will test whether a weekly injection of a GLP-1 receptor agonist (a type 2 diabetes drug) can improve gum health in 30 adults who have both periodontitis and diabetes. Researchers will measure changes in gum pocket depth, bleeding, and tooth mobility. The goal is…

This study aims to understand how certain immune proteins, called NOD1 and NOD2, relate to gum disease. Researchers will collect saliva and blood samples from 75 people with healthy gums, gingivitis, or periodontitis. They will measure levels of these proteins and other markers t…

This study compares levels of oxidized LDL (a type of 'bad' cholesterol linked to heart disease) in the gum fluid of people with advanced gum disease versus those with healthy gums. Researchers aim to better understand the connection between gum inflammation and heart health. The…

This study will examine 60 adults with psoriasis to understand why they often have higher rates of gum disease. Researchers will measure immune-related proteins and stress hormones in saliva and gum fluid, and also ask about appearance-related anxiety. The goal is to uncover biol…