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Could a common tooth enamel defect trigger hidden gum inflammation?

NCT ID NCT07701642

Knowledge-focused Sponsor: Marmara University Source: ClinicalTrials.gov ↗

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 14, 2026 · Last updated Jul 15, 2026 · Updated 1 time

Summary

This study looks at whether children with molar-incisor hypomineralization (MIH) — a condition that weakens tooth enamel — have different levels of gum inflammation markers compared to children without MIH. Researchers will measure inflammatory substances in gum fluid from 76 children aged 8-13 who need gum treatment for gingivitis. The goal is to understand if MIH affects gum health beyond the enamel defects.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If MIH is linked to higher gum inflammation, it could lead to better dental care for affected children.
What could go wrong
This is a small observational study, so it can only show associations, not cause and effect. Results may not apply to all children with MIH.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 76 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Jul 2026

An estimate. Start dates often move.

Expected to finish

Nov 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Systemically healthy children aged 8-13 years with gingivitis requiring initial periodontal therapy. The study includes children with molar-incisor hypomineralization (MIH) affecting at least three permanent first molars (study group) and age-matched children without MIH (control group).

Ages

8 to 13 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Systemically healthy children aged 8-13 years (both sexes). * Children who demonstrate adequate cooperation for dental treatment and study procedures (Frankl Behavior Rating Scale score ≥3). * Study group: Children with molar-incisor hypomineralization (MIH) affecting at least three permanent first molars and requiring initial periodontal treatment for gingivitis. * Control group: Children without molar-incisor hypomineralization who require initial periodontal treatment for gingivitis. * Presence of gingivitis requiring initial periodontal therapy. Exclusion Criteria: * Use of antibiotics within the previous 1 month. * Radiographic evidence of periodontal destruction. * History of periodontal treatment within the previous 3 months. * Presence of systemic, chronic, or metabolic diseases. * Ongoing active orthodontic treatment. * Developmental enamel defects other than molar-incisor hypomineralization. * History of premature birth.

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Conditions

The condition(s) this trial relates to.

gingivitis Molar Hypomineralization

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Molar-incisor hypomineralization (MIH)

How to take part

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  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

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Contacts and locations

Locations

  • Marmara Üniversitesi Recep Tayyip Erdoğan Külliyesi Sağlık Yerleşkesi, Diş Hekimliği Fakültesi

    Istanbul, MALTEPE, 34854, Turkey (Türkiye)

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