Chilling a tooth from the inside: could cold saline ease Post-Root-Canal pain?

NCT ID NCT07733700

Not yet recruiting Symptom relief Sponsor: Alanya Alaaddin Keykubat University Source: ClinicalTrials.gov ↗

First seen Jul 29, 2026 · Last updated Jul 30, 2026 · Updated 1 time

Summary

This trial tests whether flushing the inside of a tooth with cold saline (about 2.5°C) after root canal retreatment can lower pain and inflammation. One hundred adults needing retreatment on a lower premolar will be randomly assigned to receive either cold or room-temperature saline. Researchers will measure pain levels and inflammatory markers in saliva and gum fluid over a week to see if the cold rinse makes a difference.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: intracanal cryotherapy (cold saline irrigation at 2.5°C)
What this could lead to: If it works, this could offer a simple, low-cost way to reduce pain and inflammation after root canal retreatment.
What could go wrong: This is a small, early-stage trial. The cooling effect may not significantly reduce pain or biomarkers, and results may not apply to other teeth or patients.

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Conditions

The condition(s) this trial relates to.

chronic apical periodontitis hereditary sensory and autonomic neuropathy Pain, Postoperative

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ASYMPTOMATIC APICAL PERIODONTITIS CRYOTHERAPY ENDODONTIC RETREATMENT

Contacts and locations

Locations

Alanya Alaaddin Keykubat University, Faculty of Dentistry

Antalya, ALANYA, 07400, Turkey (Türkiye)

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