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Can a hyaluronic acid gel help Smokers' gums heal better?

NCT ID NCT07597213

Not yet recruiting Disease control Sponsor: Marmara University Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether adding hyaluronic acid gel to standard deep-cleaning treatment improves gum healing in smokers with advanced periodontitis. Twenty-three smokers will receive the standard cleaning, then some gum pockets will also get the gel. Researchers will measure gum pocket depth, attachment levels, and markers of inflammation and bacteria over six months.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
hyaluronic acid gel
What this could lead to
If it works, this could point toward a simple add-on treatment to improve gum healing in smokers with periodontitis.
What could go wrong
This is a very small early study (23 people) with no blinding, so results may not be reliable or apply to non-smokers. The benefit may be minimal or absent.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

periodontitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

8-OHDG HYALURONIC ACID METALLOTHIONEIN ORAL MICROBIOTA OXIDATIVE STRESS PERIODONTAL THERAPY PERIODONTITIS

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Department of Periodontology, Faculty of Dentistry, Marmara University

    Istanbul, Turkey (Türkiye)

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