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Can everyday supplements boost gum disease therapy?

NCT ID NCT07827391

Symptom relief Sponsor: Izmir Katip Celebi University Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 18, 2026 · Last updated Sep 18, 2026

Summary

Researchers compare whether adding omega-3 or resveratrol supplements to standard non-surgical gum treatment improves periodontal health in healthy non-smokers with periodontitis. The study looks back at records from 60 patients split into three groups: those who took resveratrol, those who took omega-3, and those who took no supplements. They measure changes in gum pocket depth, attachment level, and bleeding at one and three months after treatment. The goal is to see if either supplement provides extra benefit beyond standard treatment alone.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
omega-3 fatty acids and resveratrol dietary supplements
What this could lead to
If the supplements help, they could offer a low-cost, easy addition to standard gum disease treatment that reduces inflammation and improves outcomes.
What could go wrong
This is a small, retrospective study, so it cannot prove cause and effect. The supplements may show no added benefit, and results may not apply to smokers or people with other health conditions.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 60 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jan 2025

Expected to finish

Mar 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

The study population consists of patients aged 18-65 years who were diagnosed with periodontitis and met the predefined eligibility criteria. A total of 60 patients were included in the study and categorized into three groups according to their recorded supplementation status: a trans-resveratrol supplementation group, an omega-3 supplementation group, and a non-supplemented control group receiving non-surgical periodontal treatment without resveratrol or omega-3 supplementation. All patients received non-surgical periodontal treatment.

Ages

18 to 65 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Presence of at least 20 natural permanent teeth, * Age between 18 and 65 years, * Non-smoker status, * No use of antibiotics, anti-inflammatory drugs, or systemic corticosteroids within the previous 6 months, * No known history of hypersensitivity or allergic reactions to resveratrol, omega-3 fatty acids, or dietary supplements containing these components, * No periodontal treatment within the previous 6 months, * Absence of any oral or other systemic disease, * Not being pregnant or lactating. Exclusion Criteria: * Presence of fewer than 20 natural permanent teeth, * Age younger than 18 years or older than 65 years, * Current smoking, * Use of antibiotics, anti-inflammatory drugs, or systemic corticosteroids within the previous 6 months, * Known hypersensitivity or allergic reactions to resveratrol, omega-3 fatty acids, or dietary supplements containing these components, * Periodontal treatment within the previous 6 months, * Presence of any oral or systemic disease, * Pregnancy or lactation.

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Conditions

The condition(s) this trial relates to.

periodontitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Periodontitis

Contacts and locations

Locations

  • İzmir Katip Çelebi University, Faculty of Dentistry

    Izmir, İzmir, 35640, Turkey (Türkiye)

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