Gum disease breakdown? new peptide gel aims to regrow bone

NCT ID NCT07581613

Not yet recruiting Disease control Sponsor: Siddharth Shanbhag Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests a new gel made from peptides (protein fragments) to see if it can help regrow bone and tissue damaged by gum disease. Forty adults with advanced periodontitis will receive either the new peptide gel or a standard hyaluronic acid gel during surgery. Researchers will track bone healing and gum attachment over one year to compare safety and effectiveness.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: proline-rich peptide hydrogel (PeriHeal)
What this could lead to: If it works, this could offer a new option to help regrow bone and tissue lost to gum disease, potentially improving tooth support.
What could go wrong: This is an early Phase 1/2 trial with only 40 people, so results are preliminary. The new hydrogel may not work better than existing treatments, and side effects are still being studied.

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Conditions

The condition(s) this trial relates to.

periodontal disorder periodontitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

INTRABONY PERIODONTAL DEFECTS PERIODONTAL DISEASE

Contacts and locations

Locations

Faculty of Dentistry, University Complutense of Madrid

Madrid, Spain
Faculty of Dentistry, University of Oslo

Oslo, 0455, Norway

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