Can a gel under the gums regrow bone in diabetic gum disease?
NCT ID NCT07753317
First seen Aug 07, 2026 · Last updated Aug 12, 2026 · Updated 2 times
Summary
This trial tests whether applying a gel containing either metformin or zoledronate under the gums can improve healing of bone defects caused by periodontitis in people with well-controlled type 2 diabetes. Participants receive standard deep-cleaning treatment, and some also get one of the gels or a placebo. The study measures changes in bone defect depth and gum attachment levels to see if the gels help.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- 1% metformin gel or 0.05% zoledronate gel, applied under the gums as an add-on to minimally invasive nonsurgical treatment
- What this could lead to
- If effective, these gels could offer a simple, targeted way to improve bone healing and gum health in people with diabetes and periodontitis, potentially reducing the need for surgery.
- What could go wrong
- This is a small, early-stage trial, so results may not apply broadly. The gels might not provide extra benefit over standard treatment, and there is a risk of local irritation or other side effects.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.