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Could a common fruit replace harsh chemicals in root canals?

NCT ID NCT07688005

Disease control Sponsor: Postgraduate Medical Institute, Lahore Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 07, 2026 · Last updated Jul 08, 2026 · Updated 1 time

Summary

This study tests whether amla (Emblica officinalis), a medicinal plant, can replace standard sodium hypochlorite as a disinfectant during root canal treatment. The trial includes 66 people aged 18–50 with infected single-rooted front teeth. Researchers measure how well each solution kills Enterococcus faecalis bacteria and track pain and healing. If amla works as well, it could offer a gentler, natural alternative.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Emblica officinalis (Amla) solution
What this could lead to
If effective, amla could offer a natural, less irritating alternative to standard root canal disinfectants, reducing side effects while still clearing infection.
What could go wrong
This is a small, early-stage trial (66 people) comparing a natural remedy to a well-established treatment. Amla may prove less effective at killing bacteria or not provide better healing.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 66 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Jul 2026

An estimate. Start dates often move.

Expected to finish

Sep 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 50 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Co-operative patients of both sexes aged between 18-50 years * Patients belonging to ASA classification I and II (mild to moderate systemic disease). * Permanent mature single-rooted and single canal teeth. * Patients with pulp necrosis / apical periodontitis (primary endodontic infection with periapical radiolucency) will be included. * Adequate crown structure. * Probing level \</= 3mm * Patients not taking antibiotics for the last two weeks (pragmatic approach). Exclusion Criteria: * ●Patients with ASA Classification III, IV, V and VI or any other congenital disease. * Patient with liver failure and patient on blood thinning medication will be excluded. * Teeth with Multiple roots and canals. * Teeth with calcified pulp chamber. * Teeth with previous endodontic therapy performed. * Aberrant anatomy. * Teeth associated with vertical root fracture and coronal perforation. * Patient taking antibiotics in the last two weeks.

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Conditions

The condition(s) this trial relates to.

dental pulp necrosis periapical periodontitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Pulp necrosis, apical periodontitis

How to take part

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  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

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Contacts and locations

Locations

  • Punjab Dental Hospital, Lahore

    Lahore, Punjab Province, 54000, Pakistan

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