Mouthwash may harm good bacteria – new study to test which ones are safe
NCT ID NCT07356271
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study will test several over-the-counter mouthwashes to see how they affect the balance of bacteria in the mouth and whether they influence heart health. Researchers will recruit 200 adults with or without gum disease from dental clinics and a university campus. The goal is to find out which mouthwashes effectively reduce plaque without disrupting the oral microbiome.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
mouthwashes (chlorhexidine, CPC, hydrogen peroxide, essential oils)
What this could lead to
If it works, this could help identify which mouthwashes are safe for daily use without harming healthy oral bacteria, and may point to links between mouthwash use and heart health.
What could go wrong
This is a very early, small study (200 people) that hasn't started yet. It only looks at effects in the short term, and results may not apply to everyone, especially those with health conditions like diabetes or hypertension.
Disclaimer
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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